Hereditary Disease Genes Occur Throughout the Human Body

A new study shows that genes associated with hereditary diseases occur throughout the human body.

The study by Esti Yeger-Lotem et al. got published in PLOS Computational Biology and used network biology to model the interactions between proteins associated with diseases such as Parkinson's in different tissues. Using these networks, they show that proteins carrying the disease are found throughout the body.

Hereditary Diseases Affecting the Skeleton are Heterogeneous
A paper titled Rare Bone Diseases and Their Dental, Oral, and Craniofacial Manifestations was published by the International and American Associations for Dental Research (IADR/AADR).

In tissues vulnerable to hereditary diseases, the networked proteins had unique interactions relevant for the mechanism of the disease. Disease causing genes tend to be more highly expressed. The authors demonstrated through several examples that tissue-specific protein interaction can highlight disease mechanisms, and thus, owing to their small number, provide a powerful filter for interrogating the origins of disease.

These results offer a powerful filter that can enhance the search for new therapeutic targets for many hereditary diseases.

Source-Eurekalert

Understanding of Hereditary Diseases That Lead to Blindness may be Improved by Mice Study
A novel technique, consisting of the induction of neuronal degeneration, for intense light exposure in the mouse's retina is being used as an experimental model of retinitis pigmentosa

Stem Cell Model for Hereditary Disease Developed
Novel stem cell model for hereditary condition Gaucher disease could pave way for more effective therapies for this and other diseases such as Parkinson's, say scientists.

Mechanism Behind Inherited Muscle Atrophy Uncovered
Belgian researchers seem to have identified the mechanism behind Charcot-Marie-Tooth (CMT) neuropathy, a hereditary disease.