Acute hepatocellular injury is a commonly encountered phenomenon in patients with cholelithiasis and concomitant common bile duct (CBD) stones. However, in clinical practice, it seemed to occur also in cholelithiasis patients without evidence of CBD stones. Its incidence and final outcome necessitated clarification.
A research article to be published on August 14, 2009 in the World Journal of Gastroenterology addresses this question. The research team, led by Dr. Shou-Chuan Shih from Mackay Memorial Hospital (Taiwan, China) investigated acute transient hepatocellular injury in patients with cholelithiasis and cholecystitis but no evidence of choledocholithiasis.
Cholelithiasis - Treatment
Removal of the gallbladder (cholecystectomy) is treatment of symptomatic choleithiasis in patients who are fit for operation. Only gallstones that cause symptoms or complications require treatment.
Removal of the gallbladder (cholecystectomy) is treatment of symptomatic choleithiasis in patients who are fit for operation. Only gallstones that cause symptoms or complications require treatment.
They found that, in 96 patients with cholelithiasis and cholecystitis without evidence of CBD stones, 49 (51.0%) had an alanine aminotransferase level elevated to 2-3 times the upper limit of normal, and 40 (41.2%) had an elevated aspartate aminotransferase level. Similar manifestations of hepatocellular injury were, as would be expected, even more obvious in the 90 patients with CBD stones. These markers of hepatocellular injury resolved almost completely within 2 week to 1 moth after cholecystectomy. Compared to 59 patients with histologically less severe cholecystitis.
The result indicated that acute hepatocel lular injury in cholelithiasis and cholecystitis without choledocholithiasis is mild and transient. Hyperbilirubinemia and leukocytosis may predict severe inflammatory changes in the gallbladder.
Gallstones (Cholelithiasis) - Causes - Symptoms - Diagnosis - Treatment - FAQs
The gallbladder is a small pear-shaped organ that stores and concentrates bile Gallstones are crystalline stones that form inside the gall bladder or bile duct.
The gallbladder is a small pear-shaped organ that stores and concentrates bile Gallstones are crystalline stones that form inside the gall bladder or bile duct.
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Can Early Acute Hepatic Radiation Injury be Evaluated by 31P MRS?
The gold standard test for diagnosing acute hepatic injury is liver biopsy.
The gold standard test for diagnosing acute hepatic injury is liver biopsy.
