About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Helicobacter Pylori Uses New Strategy to Target Mitochondria

by Bidita Debnath on December 31, 2017 at 10:12 PM
Font : A-A+

Helicobacter Pylori Uses New Strategy to Target Mitochondria

Helicobacter pylori or H. pylori is a common type of bacteria that grows in the digestive tract and has a tendency to attack the stomach lining. It infects the stomachs of roughly 60 percent of the world's adult population.

Infection with H. pylori is acquired in childhood and lasts for decades. H. pylori is the main risk factor for gastric cancer and is linked to more than 80% of cases. Gastric cancer, the third most common cause of cancer-related death, is often associated with a poor prognosis because it tends to be diagnosed at an advanced stage. It is responsible for about 800,000 deaths each year worldwide.

Advertisement


H. pylori has several virulence factors that interact with specific targets in the cell and directly affect the severity of gastric disease. Vacuolating cytotoxin A (VacA) was previously the only main H. pylori factor known to act on mitochondria, causing cellular membrane and organelle dysfunction and leading to cell death.

Scientists from the Institut Pasteur and the CNRS have discovered that H. pylori uses at least two additional strategies to target mitochondria. These strategies do not lead to cell death but maintain an environment that is conducive to bacterial proliferation.
Advertisement

Their results show that H. pylori affects both mitochondrial transport systems (used to transfer proteins into mitochondria) and the machinery for the replication and maintenance of the mitochondrial genome. The scientists also discovered that, contrary to what was previously believed, VacA is not the only H. pylori component capable of affecting mitochondria. This suggests that the bacteria may produce other mitochondria-interacting factors that have not been yet identified.

As Miria Ricchetti, joint last author of the paper and a scientist at the Institut Pasteur, explains, "the damage to mitochondria caused by H. pylori bacteria is temporary and disappears once the infection has been eliminated. Despite remarkably high levels of stress, mitochondria, like cells, can remain functional and withstand infection for longer than previously thought. It is important for us to bear this in mind when looking for strategies to inhibit the bacterium's pathogenic potential."

Eliette Touati, joint last author of the paper and a scientist at the Institut Pasteur, adds: "We have observed in a mouse model that this type of damage is associated with a worsening of gastric lesions. The damage may therefore affect the chronicity and severity of infection by H. pylori. Understanding these new interactions between pathogen and host cells (via mitochondria) is vital for the development of effective strategies to combat H. pylori infection. The aim is to reduce the persistence of the bacteria in the stomach and curb associated conditions, especially cancer."

Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Advertisement
News Category
What's New on Medindia
Menstrual Disorders
Coffee May Help You Fight Endometrial Cancer
Fermented Skin Care
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Acid Peptic Disease 

Recommended Reading
Neutrons Identify Critical Details in Gastric Cancer
Understanding the details of the enzyme, and thus the Helicobacter pylori bacteria's metabolism and ...
Biomarker Identified To Treat Gastric Cancer: Study
Gastric cancer is the second deadliest disease in the world. A new protein biomarker has been ......
Beware! Beedi Smoking Turns Out to be a Potential Risk Factor for Gastric Cancer
Many are aware that smoking can cause lung and oral cancer but a new study reveals that smoking ......
New Molecule Discovered That Helps Gastric Cancer Patients Survive Longer
Patients whose primary gastric cancer lesions express high levels of microRNA 506 have ......
Acid Peptic Disease
Acid peptic diseases are a collective disorder affecting millions of people worldwide. A general des...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2022

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use
open close
ASK A DOCTOR ONLINE
I have read and I do accept terms of use - Telemedicine

Advantage Medindia: FREE subscription for 'Personalised Health & Wellness website with consultation' (Value Rs.300/-)