In Memphis, Tennessee, at least nine people due to the heat wave. A woman fell victim to the high temperatures Thursday while waiting to visit Elvis Presley's grave at Graceland, the report said Friday.
A nuclear plant had to shut down one of its units in Alabama because the water being drawn from the Tennessee River was too hot.
The brutal heat has claimed at least four victims in Georgia.
In Alabama, bus drivers said the temperatures inside their vehicles have climbed to as high as 50 degrees Celsius during the heat wave.
Weather forecasters expect the temperature to cool down a little bit over the weekend in these areas.