About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Heart Failure Treatment Effective With Umbilical Cord Stem Cells

by Julia Samuel on September 27, 2017 at 5:31 PM
Font : A-A+

Heart Failure Treatment Effective With Umbilical Cord Stem Cells

Treatment with umbilical cord-derived stem cells for heart failure can lead to notable improvements in heart muscle function and quality of life, according to a new study published in Circulation Research.

"We are encouraged by our findings because they could pave the way to a non-invasive, promising new therapy for a group of patients who face grim odds," said study corresponding author Fernando Figueroa, M.D., professor of medicine at the Universidad de los Andes in Chile.

Advertisement


In this trial, 30 patients, ages 18 to 75, with stable heart failure receiving optimal drug therapy underwent intravenous infusions with either umbilical cord-derived stem cells or placebo. The umbilical cords were obtained from full-term human placentas from healthy donors by cesarean section after informed consent.

Compared to the placebo treatment, the stem cell therapy:

  • showed sustained and significant improvement in the hearts ability to pump blood in the year following treatment
  • resulted in greater improvements on measures of daily functional status and quality of life
  • was safe with no adverse effects or development of alloantibodies, a common immune complication in patients receiving organ transplants or blood transfusions.
Researchers have previously assessed the potential of bone marrow-derived stem cells as treatment; however, intravenous umbilical cord-derived stem cells have never been evaluated. The latter type has been particularly appealing because they are easily accessible, widely available, unlikely to cause immune complications and free of the ethical concerns that surround embryonic stem cells, the researchers noted.
Advertisement

"Standard drug-based regimens can be suboptimal in controlling heart failure, and patients often have to progress to more invasive therapies such as mechanical ventricular assist devices and heart transplantation," said lead study author Jorge Bartolucci M.D., a cardiologist from Cells for Cells and professor at the Universidad de los Andes.

Heart failure, marked by the heart muscle's inability to pump blood efficiently, affects some 37 million people worldwide. Despite medical advances, half of patients diagnosed with heart failure will die within five years of diagnosis, according to Figueroa. If affirmed in larger studies, these findings could provide a promising new treatment option for a condition that currently has few.

Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
News Category
What's New on Medindia
Printed Temperature Sensors help with Continuous Temperature Monitoring
Health Benefits of Giloy
Breast Cancer Awareness Month 2021 - It's time to RISE
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Stem Cells - Cord Blood Stem Cells - Fundamentals Parkinsons Disease Surgical Treatment Genetics and Stem Cells Congenital Heart Disease Heart Healthy Heart Pulmonary Arterial Hypertension Statins Mitral Valve Prolapse 

Recommended Reading
Congestive Heart Failure
Congestive heart failure (CHF) is a condition in which the heart fails to work adequately as a pump ...
Cardiogenic Shock
Cardiogenic shock is defined as reduced cardiac output due to inability of the heart to pump ......
Heart Cancer
Malignant heart cancer is extremely rare. Benign tumors of the heart too are rare, with early ......
Pulmonary Edema
Pulmonary edema or fluid in the lungs is caused by congestive heart failure and several other ......
Congenital Heart Disease
Heart diseases that are present at birth are called “ Congenital heart diseases”....
Mitral Valve Prolapse
Mitral Valve Prolapse is a relatively common condition and causes leakage of blood through the valve...
Pulmonary Arterial Hypertension
It can be a serious condition affecting the heart. It is defined as mean pulmonary arterial pressure...
Statins
Statins are new wonder drugs that are proving to be efficacious, not merely in relieving symptoms bu...
Stem Cells - Fundamentals
Encyclopedia section of medindia gives general info about Stem Cells...
Stem Cells - Cord Blood
Encyclopedia section of medindia gives general info about Cord Blood...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use