
According to a new study published online by 'The Lancet Neurology', early use of available heart failure drugs slows the progressive decline in heart function before symptoms are apparent in boys and young men with Duchenne muscular dystrophy (DMD).
DMD is a genetic disorder. In people with DMD the body lacks dystrophin, a protein that helps keep muscle cells intact. This causes muscles to rapidly degenerate and weaken. DMD predominantly affects males and a majority of patients develop heart or respiratory failure, surviving into their 20s or early 30s.
Researchers tested the combination of eplerenone and either an ACE inhibitor or an angiotensin receptor blocker (ARB) to decrease the progression of heart muscle disease, a leading cause of death in boys and young men with DMD. They enrolled 42 boys with DMD who also showed evidence of early heart muscle damage by cardiac magnetic resonance imaging. These boys were randomized to receive one pill of either 25 milligrams of eplerenone or placebo daily for one year. All the subjects received background therapy with either an ACE inhibitor or ARB. The patients had cardiac MRIs done before and again at 6 and 12 months after starting the study medicine. The research team reported that after 12 months the further decline in left ventricular function was significantly less in the eplerenone treatment group than in those on placebo.
Co-investigator of the study Dr. Linda Cripe, a pediatric cardiologist said, "This could quickly become standard of care for patients with DMD."
Source: Medindia
Advertisement
|
Recommended Reading
Latest Drug News




