About Careers Internship MedBlogs Contact us

Using Bacterial Genes to Combat Mosquito-Borne Diseases

Font : A-A+

  • The bacterium Wolbachia spreads by manipulating the host’s reproduction.
  • This bacterium uses the cytoplasmic incompatibility or CI mechanism in which sperm of infected males are made lethal to the eggs of uninfected females, thereby sterilizing the uninfected females.
  • A single pair of Wolbachia genes that produce this CI effect only when working together has been discovered.

Using Bacterial Genes to Combat Mosquito-Borne Diseases

Wolbachia is a bacteria that infects several species of bugs including species of insects, spiders, centipedes and other arthropods all around the globe.

The bacterium operates by taking over its hosts' reproduction.


Though this ability of Wolbachia have long been known, and researchers have been looking for ways to use this natural bacterium to control mosquitoes that spread human diseases, it is only now that teams of biologists from Vanderbilt and Yale Universities have identified the specific genes that confer this remarkable capability.

The two universities have applied for a patent to use these genes to genetically engineer either the bacterial parasite or the insects themselves to produce more effective methods for controlling the spread of insect-borne diseases like dengue and Zika and for reducing the ravages of agricultural pests.

"We've known for decades that one of the secrets to Wolbachia's success is that it interferes with host reproduction in order to spread itself through females. But how the bacterium did it was a major mystery for the field," said Associate Professor of Biological Sciences Seth Bordenstein, who headed the Vanderbilt contingent.

"Now we know the genes that give it this capability." Bordenstein added.

Zika and dengue is considered to be the most rapidly spreading mosquito-borne viral disease in the world.

Though Wolbachia is not normally found in Aedes aegypti, (the mosquito that spreads dengue, Zika and chikungunya viruses), a team of Australian scientists had discovered that when Wolbachia is introduced into Aedes, it prevents these disease viruses from growing.

Since the results have been promising, the scientists have been looking for ways to determine the most effective way to use Wolbachia to control Zika and dengue.

Mechanism of Manipulating Host Reproduction

Wolbachia uses a process called "cytoplasmic incompatibility" or CI to manipulate the host's reproduction.

In this process, the sperm of infected males are rendered lethal to the eggs of uninfected females.

The researchers have identified a single pair of Wolbachia genes that produce this effect only when working together. The CI genes are located in a portion of the Wolbachia genome called the eukaryotic association module, which contains genes that the bacterium appears to use to interact with its host.

When an infected male mates with an uninfected female, only few of the eggs hatch. But when an infected male mates with an infected female or when an uninfected male mates with an infected female, they produce the same number of offspring as when uninfected males and females mate.

The number of infected females produced in each generation is maximized as a result of this, which is beneficial to Wolbachia because it is only passed down through the maternal line.

"This is an extremely effective strategy. Under ideal conditions it allows Wolbachia to infect an entire host population within a few generations or years," said Bordenstein.

How Wolbachia Can Curb Spread of Viruses

"There are two basic approaches for using Wolbachia to eliminate or curb the spread of a viruses like dengue and Zika," said Bordenstein.

The first approach is a stable approach, called population replacement. It involves introducing Wolbachia to a population od both males and females infected mosquitoes, so they spread the bacteria on their own until they eventually replace the resident population.

The risk of dengue and Zika transmission drops as they spread because Wolbachia prevents these disease viruses from replicating.

The second approach, called population suppression, is to introduce copious numbers of infected males. Because the uninfected females that mate with infected males fail to reproduce, this reduces the size of the target population.

The first approach is slow but steady and will eventually lead to the reduction or virtual elimination of disease transmission. Though the second approach is faster, the insect population can rebound so it must be administered repeatedly.

The Vanderbilt researchers found that using genetic engineering to insert the Wolbachia CI genes into infected insects can strengthen the incompatibility effect and so significantly decrease the hatch rate of uninfected females who mate with infected males. As a result, it may increase the rate at which the bacterium spreads.

The next step in the research is to search for the genes in infected females that counteract CI, which rescue their eggs and allow them to hatch normally.

This achievement is described in the journal Nature in a paper titled "Prophage WO Genes Recapitulate and Enhance Wolbachia-induced Cytoplasmic Incompatibility" and in a companion article titled "A Wolbachia deubiquitylating enzyme induces cytoplasmic incompatibility" in Nature Microbiology.


  1. Seth Bordenstein et al.Prophage WO Genes Recapitulate and Enhance Wolbachia-induced Cytoplasmic Incompatibility. Nature; (2017)
  1. Seth Bordenstein et al.A Wolbachia deubiquitylating enzyme induces cytoplasmic incompatibility. Nature Microbiology; (2017)

Source: Medindia

Citations   close

Please use one of the following formats to cite this article in your essay, paper or report:

  • APA

    Dr. Meenakshy Varier. (2017, February 27). Using Bacterial Genes to Combat Mosquito-Borne Diseases. Medindia. Retrieved on Jun 28, 2022 from https://www.medindia.net/news/healthwatch/using-bacterial-genes-to-combat-mosquito-borne-diseases-168173-1.htm.

  • MLA

    Dr. Meenakshy Varier. "Using Bacterial Genes to Combat Mosquito-Borne Diseases". Medindia. Jun 28, 2022. <https://www.medindia.net/news/healthwatch/using-bacterial-genes-to-combat-mosquito-borne-diseases-168173-1.htm>.

  • Chicago

    Dr. Meenakshy Varier. "Using Bacterial Genes to Combat Mosquito-Borne Diseases". Medindia. https://www.medindia.net/news/healthwatch/using-bacterial-genes-to-combat-mosquito-borne-diseases-168173-1.htm. (accessed Jun 28, 2022).

  • Harvard

    Dr. Meenakshy Varier. 2021. Using Bacterial Genes to Combat Mosquito-Borne Diseases. Medindia, viewed Jun 28, 2022, https://www.medindia.net/news/healthwatch/using-bacterial-genes-to-combat-mosquito-borne-diseases-168173-1.htm.


News A-Z
What's New on Medindia
Vaccination  And Counter  Measures Against  Monkeypox
Indian Railways Special Concession on Health Grounds
View all
Recommended Reading
News Archive
News Category

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Weaver Syndrome Top 10 Plants that Repel Mosquitoes Naturally 

Most Popular on Medindia

Drug - Food Interactions Indian Medical Journals Sinopril (2mg) (Lacidipine) How to Reduce School Bag Weight - Simple Tips Hearing Loss Calculator Calculate Ideal Weight for Infants Loram (2 mg) (Lorazepam) Color Blindness Calculator Iron Intake Calculator Pregnancy Confirmation Calculator

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2022

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use