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Testosterone Replacement Therapy in Men May Lower Cardiovascular Risk
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Testosterone Replacement Therapy in Men May Lower Cardiovascular Risk

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Highlights
  • Lower levels of testosterone hormone may cause androgen deficiency.
  • Testosterone replacement therapy is used for androgen deficiency in men.
  • A recent study finds lowered risk of cardiovascular events among men who used testosterone replacement therapy.

Testosterone replacement therapy used for treating symptoms of androgen deficiency in men can lower the risk of cardiovascular events such as heart attack and stroke by 33% when compared to those who did not receive any hormone therapy, reveals study.

The findings of the study were published in the journal JAMA Internal Medicine.

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Lower levels of sex hormones especially testosterone may cause androgen deficiency in men. Symptoms may include loss of sexual desire, erectile dysfunction, enlargement of the breasts, hot flashes, reduced energy, irritability and depressed mood.

The decline in the level of the sex hormone may begin in the early 30s. It is estimated that about 200 men under the age of 60 had testosterone levels below normal, and two out of 10 men over the age of 60 have low levels.
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Testosterone Replacement Therapy
Testosterone Replacement Therapy can be used to treat symptoms related to androgen deficiency. This can be given in the form of injections, or can be taken either orally or topically.

T. Craig Cheetam, PharmD, MS, lead authors, Kaiser Permanente Southern California Department of Research & Evaluation, said, "Our study found no indication of an increased risk for cardiovascular events for men with androgen deficiency."

"Our hope is that these findings help alleviate the concerns that patients with androgen deficiency and their doctors may have had about prescribing and taking testosterone replacement therapy."

Research Study
The research study evaluated 44,335 men who were diagnosed with androgen deficiency from Kaiser Permanente medical centers in the Northern and Southern California between January 1, 1999, to December 31, 2010.

Out of these 44,335 men, around 8,808 men were treated with testosterone therapy and 35,527 men were never dispensed with testosterone.

Study Findings
After a period of 3.4 years the research team found,

  • Men who did not receive testosterone had 10.2% risk of heart attack, stroke during the study period.
  • Men who received testosterone replacement therapy had only 8.2% risk of heart attack or stroke during the study period.
Androgen Deficiency
Androgen deficiency is caused by genetic disorders, damage to the testes, medical problems or pituitary glands

Symptoms of Androgen Deficiency
  • Low energy levels
  • Changes in the mood
  • Poor concentration
  • Irritability
  • Reduced muscle strength
  • Low sex drive
Reference
  1. Low testosterone - ( https://www.andrologyaustralia.org/your-health/testosterone/ )


Source: Medindia

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