About Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Stem Cells To Potentially Treat Asthma

Font : A-A+

Highlights
  • Induced pluripotent stem cells are a type of pluripotent stem cell that has the ability to be differentiated into a variety of tissue types.
  • Mesenchymal stem cells (MSCs) derived from induced pluripotent cells can regenerate damaged lung tissue.
  • The MSCs reduced inflammation, airway remodeling and airway hyper-responsiveness in asthma induced mice.

Stem Cells To Potentially Treat Asthma

Asthma is a condition in which the airways of the lungs become either narrowed or completely blocked, obstructing normal breathing. This obstruction of the lungs, however, is reversible, either spontaneously or with medication.

Structural changes known as airway remodeling (AWR) characterize chronic/severe asthma and contribute to lung dysfunction.

Advertisement


A study led by scientists at Monash University has shown that a new therapy developed through stem cell technology holds promise as a treatment for chronic asthma.

Mesenchymal Stem Cells in Asthma Treatment

The Monash Biomedicine Discovery Institute (BDI) scientists provided the experimental expertise to test Cynata Therapeutics' induced pluripotent stem cell-derived mesenchymal stem cells (MSCs) in a model of experimental asthma.
Advertisement

Induced pluripotent stem cells are a type of pluripotent stem cell that can be generated directly from adult cells; they have the ability to be differentiated into a variety of tissue types and, in this case, MSCs that can regenerate damaged lung tissue.

Lead researchers Associate Professor Chrishan Samuel and Dr Simon Royce tested the efficacy of the MSCs on three key components of asthma in a preclinical model of chronic allergic airways disease: inflammation; airway remodeling (structural changes that occur in lungs as a result of prolonged inflammation); and airway hyperresponsiveness (the clinical symptom of asthma).

The study found that the MSCs could effectively reduce inflammation, reversed signs of airway remodelling and completely normalised airway/lung fibrosis and airway hyperresponsiveness, particularly when delivered intranasally.

It concluded that they may provide a novel stand-alone therapy or an adjunct therapy for groups of asthma sufferers who do not respond to current (corticosteroid) therapy.

"Most importantly, what we found was you can treat fibrosis (hardening or scarring of the lung) very effectively," said Associate Professor Samuel, who heads the Monash BDI's Fibrosis Laboratory.

"When we've tested other types of stem cells they haven't been able to fully reverse scarring and lung dysfunction associated with asthma - we've had to combine them with anti-scarring drugs to achieve that. These cells were remarkable on their own as they were able to effectively reverse the scarring that contributes to lung dysfunction and difficulty in breathing," he said.

Further research will be conducted to test the MSCs in combination with, or compared to a clinically-used corticosteroid. Clinical trials using the cells as a novel target for asthma are then envisaged.

Reference
  1. Samuel, C. S et al., Intranasal administration of mesenchymoangioblast-derived mesenchymal stem cells abrogates airway fibrosis and airway hyperresponsiveness associated with chronic allergic airways disease, FASEB Journal (2017) http:dx.doi.org/10.1096/fj.201700178R.


Source: Medindia

Citations   close

Please use one of the following formats to cite this article in your essay, paper or report:

  • APA

    Julia Samuel. (2017, July 05). Stem Cells To Potentially Treat Asthma. Medindia. Retrieved on May 22, 2022 from https://www.medindia.net/news/healthwatch/stem-cells-to-potentially-treat-asthma-171427-1.htm.

  • MLA

    Julia Samuel. "Stem Cells To Potentially Treat Asthma". Medindia. May 22, 2022. <https://www.medindia.net/news/healthwatch/stem-cells-to-potentially-treat-asthma-171427-1.htm>.

  • Chicago

    Julia Samuel. "Stem Cells To Potentially Treat Asthma". Medindia. https://www.medindia.net/news/healthwatch/stem-cells-to-potentially-treat-asthma-171427-1.htm. (accessed May 22, 2022).

  • Harvard

    Julia Samuel. 2021. Stem Cells To Potentially Treat Asthma. Medindia, viewed May 22, 2022, https://www.medindia.net/news/healthwatch/stem-cells-to-potentially-treat-asthma-171427-1.htm.

Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
What's New on Medindia
Prevent Hacking of Medical Devices: FDA Sounds Alarm
Black Water: Benefits and Uses
World Hypertension Day 2022 - Measure Blood Pressure Accurately, Control It, Live Longer!
View all
Recommended Reading
News Archive
Date
Category
Advertisement
News Category

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Childhood Asthma Asthma Stem Cells - Cord Blood Stem Cells - Fundamentals Parkinsons Disease Surgical Treatment Genetics and Stem Cells Remedies for Seasonal Allergy Relief Bone Marrow Transplantation Tissue Engineering and Regenerative Medicine 

Most Popular on Medindia

Blood Pressure Calculator Drug - Food Interactions Drug Interaction Checker Vent Forte (Theophylline) Find a Doctor Daily Calorie Requirements Loram (2 mg) (Lorazepam) Indian Medical Journals A-Z Drug Brands in India Turmeric Powder - Health Benefits, Uses & Side Effects

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2022

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use