- Induced pluripotent stem cells are a type of pluripotent stem cell that has the ability to be differentiated into a variety of tissue types.
- Mesenchymal stem cells (MSCs) derived from induced pluripotent cells can regenerate damaged lung tissue.
- The MSCs reduced inflammation, airway remodeling and airway hyper-responsiveness in asthma induced mice.
Asthma is a condition in which the airways of the lungs become either narrowed or completely blocked, obstructing normal breathing. This obstruction of the lungs, however, is reversible, either spontaneously or with medication.
Structural changes known as airway remodeling (AWR) characterize chronic/severe asthma and contribute to lung dysfunction.
‘Mesenchymal stem cells (MSCs) could effectively reduce inflammation, reverse signs of airway remodelling and completely normalise airway/lung fibrosis and airway hyper-responsiveness, particularly when delivered intranasally.’
A study led by scientists at Monash University has shown that a new therapy developed through stem cell technology holds promise as a treatment for chronic asthma
Mesenchymal Stem Cells in Asthma Treatment
The Monash Biomedicine Discovery Institute (BDI) scientists provided the experimental expertise to test Cynata Therapeutics' induced pluripotent stem cell-derived mesenchymal stem cells (MSCs) in a model of experimental asthma.
Induced pluripotent stem cells are a type of pluripotent stem cell that can be generated directly from adult cells; they have the ability to be differentiated into a variety of tissue types and, in this case, MSCs that can regenerate damaged lung tissue.
Lead researchers Associate Professor Chrishan Samuel and Dr Simon Royce tested the efficacy of the MSCs on three key components of asthma in a preclinical model of chronic allergic airways disease: inflammation; airway remodeling (structural changes that occur in lungs as a result of prolonged inflammation); and airway hyperresponsiveness (the clinical symptom of asthma).
The study found that the MSCs could effectively reduce inflammation, reversed signs of airway remodelling and completely normalised airway/lung fibrosis and airway hyperresponsiveness, particularly when delivered intranasally.
It concluded that they may provide a novel stand-alone therapy or an adjunct therapy for groups of asthma sufferers who do not respond to current (corticosteroid) therapy.
"Most importantly, what we found was you can treat fibrosis (hardening or scarring of the lung) very effectively," said Associate Professor Samuel, who heads the Monash BDI's Fibrosis Laboratory.
"When we've tested other types of stem cells they haven't been able to fully reverse scarring and lung dysfunction associated with asthma - we've had to combine them with anti-scarring drugs to achieve that. These cells were remarkable on their own as they were able to effectively reverse the scarring that contributes to lung dysfunction and difficulty in breathing," he said.
Further research will be conducted to test the MSCs in combination with, or compared to a clinically-used corticosteroid. Clinical trials using the cells as a novel target for asthma are then envisaged.
- Samuel, C. S et al., Intranasal administration of mesenchymoangioblast-derived mesenchymal stem cells abrogates airway fibrosis and airway hyperresponsiveness associated with chronic allergic airways disease, FASEB Journal (2017)