Soft or Hard Plaque - Which Poses Greater Risk of Heart Attack?

"We previously thought the lipid-laden soft plaque was more likely to rupture and cause heart attacks, but based on our new research, it's more the calcified plaque that appears to be associated with adverse cardiovascular events" said Brent Muhlestein, MD, one of the study's authors and co-director of cardiology research at the Intermountain Medical Center Heart Institute in Salt Lake City.

Intermountain Medical Center Heart Institute researchers had earlier teamed with Johns Hopkins School of Medicine and National Institutes of Health scientists to analyze the composition of plaque from 224 patients who had diabetes, but no heart symptoms.

This new research reflects more long-term findings after patients were followed for an average of nearly seven years to see if their plaque composition had predicted whether they'd have a cardiac event.

Which Type Of Coronary Artery Plaque?

In this study, through careful quantitative evaluation, the composition of coronary artery plaque identified in the subjects through CT coronary angiography was stratified proportionately into amounts of soft, calcified, and fibrous plaque and compared with future risk of unstable angina, heart attack or death.

Unexpectedly, proportionately higher quantities of calcified plaque best predicted major adverse coronary events, while soft plaque did not, researchers found.

Dr. Muhlestein said further studies are needed to verify the findings, but results from his team's research may represent a potential paradigm shift. "We need further validation to gauge the importance of why the coronary calcium score is so predictive," he said.

Although a build-up of coronary calcium doesn't go away, doctors can successfully treat the patient aggressively with statins. They know no one gets coronary calcium if they don't have plaque, even if it hasn't been seen, so anyone with coronary calcium also has atherosclerosis.

"It's a disease marker, not a risk marker. And we think it's possibly a very important predictor," said Dr. Muhlestein, who noted that having a calcium score of zero is like having a five-year warranty against heart attack -- even with high levels of low-density lipoprotein, also known as LDL or bad, cholesterol.

"The finding potentially could mean a lot of patients may not require statin therapy, even though they have high cholesterol," he said. "Maybe we can find and identify them. If there's no atherosclerosis, you're not going to have a heart attack. So the coronary calcium score may allow us to much more effectively select who we treat."

Using computed tomography (CT) images of the heart and other types of imaging, build-up of dangerous coronary plaques--which restrict the flow of blood to the heart can be detected. Coronary calcium builds up at the site of coronary plaque, so a coronary artery calcium scan can be effective in detecting plaques.

Reference

1. Brent Muhlestein et al., New study finds potential breakthrough in determining who's at risk for heart attacks, American College of Cardiology's 66th Annual Scientific Session (2017).

Source: Medindia