About My Health Careers Internship MedBlogs Contact us

Scientists Target Medications for Depression Treatment

Font : A-A+

  • Depression is a common mood disorder affecting millions of people around the world.
  • Antidepressant drugs are prescribed for the treatment of depression.
  • A Research team from Texas Tech Health Science Center discovered Bupropion its metabolite to block serotonin type 3A receptors.

Scientists Target Medications for Depression Treatment

Depression is one of the common and serious mood disorder that affect millions of people around the world. It can occur at any age and usually worsen conditions like diabetes and heart diseases.

According to the World Health Organisation, around 350 million people suffer due to depression. Number of antidepressants are prescribed for the treatment. And many FDA drugs are found to cause serious side effects.


A research team from Texas Tech Health Science Center led by Michaela Jansen, Pharm.D., Ph.D., recently examined the ability of bupropion and its metabolite to block the action of serotonin type 3A receptor (5HT3ARs).

Previous studies on Bupropion were based on the discovery of reuptake inhibitors as molecular targets for the drug within the brain network and in 1999 the drug was also found to inhibit nicotinic receptors and block smoking cessation.

The recent study of the drug was published in the september issue of the journal Neuropharmacology.

Serotonin type 3A receptors are pentameric (five membered) ligand gated ion channels (pLIC) and implicate the development of anxiety and psychiatry disorders like anxiety, depression, addiction, irritable bowel syndrome and cognitive function.

Akash Pandhare, M.D., Ph.D, author and scientist at the TTUHSC Department of Cell Physiology and Molecular Biophysics, "For a long time, the blockade of dopamine and norepinephrine reuptake by the antidepressant bupropion within the hypofunctioning central nervous system monoamine systems has remained one of the pharmacological underpinnings for its therapeutic efficacy."

"This study for the first time established the 5-HT3ARs as a hitherto unidentified molecular target of bupropion." he added.

The research findings were also found to demonstrate clinical relevant concentration of receptor blockade by both the drug and its metabolite. The findings will now be a part of the pharmacy and medical text books.

The author also said that psychiatrist will now have a better understanding of the mechanism behind antidepressant drugs before prescribing.

Source: Medindia

News A-Z
News Category
What's New on Medindia
Guide to Brushing Your Teeth the Right Way
Resting Heart Rate
Is COVID-19 Vaccination during Pregnancy Safe?
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Adolescence Depression Drug Toxicity Depression Stress Relief Through Alternative Medicine Andropause / Male Menopause Pregnancy and Complications Bereavement Holistic Management for Depression Tourette Syndrome Dealing with Menopause symptoms through lifestyle changes 

Recommended Reading
This medication is prescribed for depression and smoking cessation. It increases the levels of ......
Depression Screening Test
Online Depression Screening Test tells if you have mild or chronic depression based on your ......
Quiz on Antidepressants
The use of antidepressants is quite common with an increase in stress-related depression of the ......
Prescriptions For Anti-depressants And Diabetes Drugs On The Rise In U.K
Prescriptions dished out for depression and diabetes have almost doubled in the past decade....
Andropause / Male Menopause
Andropause or male menopause causing low libido in a man is due to decreasing level of male hormones...
Bereavement refers to grief, pain and sadness following the loss of a loved one, especially during t...
Dealing with Menopause symptoms through lifestyle changes
You can deal with menopause symptoms such as hot flashes, weight gain and forgetfulness by making si...
Depression is one of the most common mental disorders affecting approximately 340 million people in ...
Drug Toxicity
Drug toxicity is an adverse reaction of the body towards a drug that results as a side effect of a d...
Holistic Management for Depression
Depression is a common disorder and many worldwide suffer from depression. Early recognition of symp...
Pregnancy and Complications
In-depth guide for expecting mothers to overcome health complications related to early or late pregn...
Tourette Syndrome
Tourette syndrome (TS) is a neurological disorder wherein the affected person makes repetitive and s...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use