One Amino Acid can Improve Birth Outcomes

Highlights

Pregnant women with malaria had less L-arginine and were associated with worse pregnancy outcomes
Nitric oxide plays a key role in development of blood vessels in the placenta, and its synthesis requires L-arginine
L-arginine supplementation in pregnant women with malaria can improve fetal weight and viability

Pregnant women infected with malaria have lower levels of L-arginine (essential amino acid) and are more likely to experience complications like stillbirths and low birth weight infants. //

Worldwide, malaria infection in pregnancy (MIP) is a leading cause of maternal-child morbidity and mortality and reducing adverse birth outcomes is a global health priority. However, only a few safe and effective interventions exist.

Malaria During Pregnancy- Prevention Strategies in Kenya
Malaria infection during pregnancy is a significant health problem to both the mother and the unborn child: Centres for Disease Control and Prevention (CDC).

‘L-arginine and nitric oxide are depleted during malaria infection in pregnancy (MIP) and supplementation of L-arginine can improve fetal weight and viability.’

Tweet it Now

Chloe McDonald and colleagues found that low levels of L-arginine in about 384 pregnant women were associated with worse pregnancy outcomes in Malawi.

Supplementation of L-arginine

The research team studied the pregnant mice and found that the ones infected with malaria benefited from L-arginine supplementation, which increased viability and birth weights among the young one’s delivered.

Malaria During Pregnancy Can be Influenced by Placental Blood Flow
During pregnancy, malaria causes a range of adverse effects, including abortions, stillbirths, premature delivery and low infant birth weight.

The results showed that the amino acid plays a vital role in the synthesis of nitric oxide, which helps in the development of blood vessels in the placenta.

Imaging of the pregnant mice with malaria was used to confirm how L-arginine supplementation can help reduce inflammation and prompts vascular development in the placenta, said McDonald et al.

Can Malaria During Pregnancy Affect Your Baby�s Immunity?
Mothers infected with malaria during pregnancy could pass on their cells to the baby and affect their immunity, finds a study.

Nearly 125 million women become pregnant every year in endemic malaria regions and where their diets are deficient in L-arginine.

In a related Focus, the "potential simplicity, affordability and practicality" of amino acid supplementation for these women were discussed by James Beeson and colleagues.

Mother's Malaria Infection During Pregnancy can Affect Memory in Offspring
Young mice that had been exposed to malaria in pregnancy had impaired learning and memory and showed depressive-like behavior that persisted to adulthood.

Novel interventions aimed to promote placental function can help improve birth outcomes for MIP and also for other causes of adverse pregnancy outcomes associated with placental insufficiency.

What is Malaria?

Malaria is one of the most serious diseases passed on to humans by mosquitoes. It is prevalent in many parts of the world.

Anopheles mosquitoes are responsible for spreading malaria to human beings, who is the sole victim of the parasite.

Plasmodium falciparum is the most common of the five species of mosquitoes that cause malaria. It is considered to be a leading cause of death in low and middle-income countries.

Children under the age of 5 and pregnant women are at a higher risk of malaria.

One of the most disturbing factors about it is that resistance of the malaria parasite to anti-malarial drugs is increasing and becoming more widespread. These mosquitoes thrive only in tropical climate and cannot survive in cold areas.

Malaria in Pregnancy

Malaria infection during pregnancy is a public health problem and poses significant risks for the pregnant woman, fetus, and the newborn child.

Malaria infection during pregnancy and low birth weight is the result of Plasmodium falciparum infection.

Malaria has a propensity for grading primips and highly prevalent during 2nd trimester.

Congenital malaria due to vertical transmission from mother predisposes to low birth weight IUGR and abortion. Other significant implications are Anemia, Hypoglycemia lung injury and ARDS.

Source-Medindia