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Now Silkworms to Repair Damaged Eardrums
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Now Silkworms to Repair Damaged Eardrums

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Highlights:
  • Chronic middle ear disease can lead to infection, hearing loss and perforated eardrums
  • Patients with chronic middle ear infections may need several surgeries to treat eardrum damage
  • An Australian research team has developed an ear implant device called ’ClearDrum’ using silk. The implant is strong, bio-compatible and can improve patients’ hearing in just one procedure

Silkworms might be used to repair damaged eardrums in the future. A device that incorporates silk in an ear implant has been developed by research teams based in Perth and Melbourne.

The device named "ClearDrum" looks like a contact lens on which the patient's cells can grow. The research teams are moving towards the clinical trials of ClearDrum.

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Silk was the preferred choice because it was flexible, said Professor Marcus Atlas, Perth-based surgeon.

"We felt that it had shown previously to support cell growth and proliferation, and the ability to be able to change into various forms was a really appealing thing for us, particularly when we started to mix it with other products to create different mechanical and acoustic criteria," said Professor Atlas.
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How is Silk used to Make ClearDrum?

The silk is degummed (removal of the sticky substance called sericin). The derivative fibroin, a protein present in the silk is then heated into a liquid and combined with glycerol and polyurethane to create a scaffold.

The cells called keratinocytes, migrate and move across the scaffold, which helps the healing process. The ClearDrum is the first implant that mimicked a human ear drum.

As the name suggests, ClearDrum is transparent. ClearDrum can improve patient's hearing as it can transmit the sound better.

"We saw that silk had this ability to become a really strong biological membrane that would support cell growth," said Professor Atlas.

Chief Executive of the Ear Science Institute Sandra Bellekom, said, "We used silk because we know that it works. It needed to be strong and flexible with acoustic properties and preferably transparent."

The middle ear is a very noxious environment. When there is a disease, a lot of pressure changes take place, making the environment moist. So, the middle ear is not the easiest place to create an implant, said Bellekom.

ClearDrum acts as a framework for the patient's own cells to grow over the top and to patch up the perforation over time. The implant is placed under the eardrum. In patients with simple or small perforation, the implant would dissolve, while for more complex or larger perforations, the implant would remain.

For years, surgeons around the world had been harvesting tissue for eardrum perforations and many organizations have been trying to develop a suitable device for the ear, said Bellekom.

"We have extensively researched our technology over the past decade, and we've been able to produce 34 peer-reviewed journal articles which attest to the quality of our science. But the real truth of the matter is in translating that into human patients."

A clinical trial of ClearDrum is set to happen with the grant of nearly $4 million from the UK-based charity, the Wellcome Trust. Patients with chronic middle ear disease (active or inactive) will be recruited for the trial. The study group will involve patients with both simple and complex perforations.

Reference :
  1. Silk provides cure for painful burst eardrums to help millions worldwide - (https://www.earscience.org.au/news/silk-provides-cure-for-painful-burst-eardrums-to-help-millions-worldwide)


Source: Medindia

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