About Careers MedBlog Contact us
Medindia LOGIN REGISTER
Advertisement

Novel Antibacterial Compound from Soil to Treat Tuberculosis

Font : A-A+

Highlights
  • Tuberculosis is a bacterial infection caused by Mycobacterium tuberculosis.
  • Drugs used for tuberculosis are becoming resistant to the bacteria.
  • Antibacterial compound obtained from soil can be a new drug lead for treating tuberculosis.

Novel Antibacterial Compound from Soil to Treat Tuberculosis

Tuberculosis (TB) caused by Mycobacterium tuberculosis is an infectious disease. Antibacterial compounds present in the soil can provide new treatment options for tuberculosis, finds a recent study from the University of Sydney.

The research team along with University Professors Richard Payne, and Warwick Britton from the Sydney have found a new compound which can be translated as a drug lead for tuberculosis.

Advertisement


The study findings were published in the journal Nature Communications.

It was estimated that around 10.4 million cases of tuberculosis and 1.4 million deaths being recorded in 2015. Tuberculosis is found to have more number of deaths than any other infectious diseases including HIV/AIDS.
Advertisement

The commonly used drugs for tuberculosis are becoming increasingly resistant to the tuberculosis bacteria. Around 480,000 cases are found to be unresponsive to the two major drugs. More than 250,000 tuberculosis deaths are from drug-resistant infections.

Antibacterial Compound from Soil
The compounds from soil were found to prevent the growth of other bacteria. The research team was able to synthesize compounds with structural variations. These compounds are potent and are referred as 'Analogues.'

These analogues are found to be effective killers for tuberculosis.

Professor Payne, said, "These analogues inhibit the action of a key protein needed to build a protective cell wall around the bacterium."

"Without a cell wall, the bacterium dies. This wall-building protein is not targeted by currently available drugs."

The analogues are found to be effective in killing the TB-causing bacteria which is present inside the macrophages.

These findings can help to create a new TB drug. Further testing and studies are required for treatment.

Tuberculosis
Tuberculosis is an infectious disease caused by bacteria. TB infections are contagious and can spread mainly through air. People with a weak immune system are more prone to tuberculosis.

Symptoms of tuberculosis

  • Bad cough
  • Weight loss
  • Fever
  • Night Sweats
  • Coughing of blood
Drugs like isoniazid, rifampicin, pyrazinamide and streptomycin are used for the treatment of tuberculosis. Multi-drug resistant tuberculosis does not respond to the standard drug treatment. The new discovery of antibacterial compound from soil can help to develop treatment for tuberculosis.

References
  1. 10 facts about tuberculosis - ( http://www.who.int/features/factfiles/tuberculosis/10_en.html )
  2. Tuberculosis - ( https://medlineplus.gov/tuberculosis.html )


Source: Medindia

Citations   close

Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
What's New on Medindia
Test  Your Knowledge on Heart
Test Your Knowlege on Genes
Obesity in Teens Make Inroads into Early Atrial Fibrillation
View all
Recommended Reading
News Archive
Date
Category
Advertisement
News Category

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Tuberculosis Tracheostomy Pleural Effusion Silicosis Screening Tests for Tuberculosis Fever Cough Symptom Evaluation Diet in Tuberculosis Stomach Tuberculosis Extra Pulmonary Tuberculosis 

Most Popular on Medindia

Nutam (400mg) (Piracetam) Iron Intake Calculator Drug - Food Interactions Calculate Ideal Weight for Infants Loram (2 mg) (Lorazepam) Blood Pressure Calculator A-Z Drug Brands in India How to Reduce School Bag Weight - Simple Tips Vent Forte (Theophylline) Sanatogen
This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use
×

Novel Antibacterial Compound from Soil to Treat Tuberculosis Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests