About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Nivolumab With Chemotherapy Benefits Acute Myeloid Leukemia (AML) Patients

Font : A-A+

Highlights
  • Acute myeloid leukemia (AML) is the cancer of the bone marrow
  • 5-year survival rate for people with AML is approximately 26%
  • Nivolumab with chemotherapy improved survival rates in AML patients

Nivolumab With Chemotherapy Benefits Acute Myeloid Leukemia (AML) Patients

The immunotherapy drug nivolumab in combination with standard chemotherapy showed more than doubled response rates and improved overall survival in patients with acute myeloid leukemia (AML), revealed preliminary findings by researchers at The University of Texas MD Anderson Cancer Center.

The results from a Phase IB/II ongoing study which paired nivolumab with azacitidine (AZA) were presented Dec. 5 at the 58th Annual Meeting of the American Society for Hematology in San Diego.

Advertisement


The study participants had previously demonstrated poor complete response and overall survival.

Study:

51 study participants with an average age of 69 years were taken into consideration. The combination of AZA and nivolumab was tested among the study participants. The combination treatment showed a response rate of 34 percent that compares favorably to a historic response rate of 12 to 15 percent with AZA alone. Media overall survival for patients treated with AZA and nivolumab was 9.3 months compared with a historic median of 4.7 months for patients treated with AZA alone.
Advertisement

Side effects were reported in 25 to 30% of patients. Side effects reported include
  • Pneumonitis (common side effect reported among the study participants)
  • Colitis
  • Skin rash
  • High liver enzyme levels
"We are working closely with colleagues in MD Anderson's immunotherapy platform to interrogate baseline and on treatment biomarkers of response and to identify additional targetable checkpoints in AML and myelodysplastic syndrome," said Naval Daver, M.D., assistant professor of Leukemia. "We hope these immune checkpoint approaches will be an additional tool to improve outcomes in leukemia patients."

Nivolumab

Nivolumab is a monoclonal antibody used to treat different types of cancers. The drug works by halting the production of cells which help to treat cancer. Indications of nivolumab include Hodgkin lymphoma, melanoma, non small cell lung cancer, renal cell carcinoma, squamous cell carcinoma.

Acute Myeloid Leukemia (AML):

AML is a type of cancer that affects the bone marrow and results in the production of abnormal myeloblasts (a type of white blood cell), red blood cells or platelets.

There are different subtypes of AML.

Acute myeloid leukemia is a disease of the older people and uncommon before the age of 45

Source: Medindia
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
News Category
What's New on Medindia
January is the Thyroid Awareness Month in 2022
Menstrual Disorders
Coffee May Help You Fight Endometrial Cancer
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Leukemia Chronic Myeloid Leukemia Acute Myeloid Leukemia Chronic Lymphocytic Leukemia Acute Lymphoblastic Leukemia Hodgkins Lymphoma Non-Hodgkins Lymphoma Chemotherapy Chemotherapy Drugs Multiple Myeloma 

Recommended Reading
Acute Myeloid Leukemia
Acute myeloid Leukemia, more popularly known by its abbreviated form AML, is a fast- evolving ......
Leukemia / Blood Cancer
Leukemia is cancer of blood-forming tissues in the body....
New Assay Developed to Treat Chemotherapy-Resistant Acute Myeloid Leukemia Tumors
The newly developed assay determines how variability within a population of tumor cells can predict ...
Vitamin C Helps Boost the Effectiveness of Acute Myeloid Leukemia Treatment
Combining vitamin C with a demethylating agent in patients with acute myeloid leukemia (AML) may ......
Acute Lymphoblastic Leukemia
Acute lymphoblastic leukemia (ALL) is the cancer of white blood cells characterized by excess lympho...
Chemotherapy
‘Chemo’ means medicine or ‘drug’; ‘therapy’ means ‘treatment’. Chemotherapy refers to the use of cy...
Chemotherapy Drugs
Chemotherapy drugs perform like ‘magic bullets’ to destroy cancer cells in the body....
Chronic Lymphocytic Leukemia
Chronic Lymphocytic Leukemia (CLL) is one of the most common types of adult leukemia and is consider...
Chronic Myeloid Leukemia
Chronic myeloid Leukemia is one of the most common types of blood cancer. It is characterized by ex...
Hodgkins Lymphoma
Hodgkins lymphoma or Hodgkins disease has the distinction of being the first cancer to be cured by c...
Leukemia
Encyclopedia section of medindia gives general information about Leukemia...
Multiple Myeloma
Multiple Myeloma caught public attention when model turned actress Lisa Ray, who worked in Deepa Meh...
Non-Hodgkins Lymphoma
Non Hodgkins Lymphoma is a cancer that affects the lymph tissues. It is made up of a wide array of ....

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2022

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use
open close
CONSULT A DOCTOR
I have read and I do accept terms of use - Telemedicine

Advantage Medindia: FREE subscription for 'Personalised Health & Wellness website with consultation' (Value Rs.300/-)