About Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

New Metabolic Molecule To Control Diet-Induced Obesity

Font : A-A+

Highlights
  • High fat diet can actually change the structure of some genes that triggers the risk of metabolic disorders.
  • A small molecule is able to change the way one particular splicing receptor protein, SRSFI, works in the bodies of mice that gained excessive weight.
  • SRSFI speeds up the metabolism of obese animals and their bodies start to function at a higher energy level shedding the excess weight.

New Metabolic Molecule To Control Diet-Induced Obesity

Obese mice fed with a small molecule that boosts metabolism may help combat obesity as it prevents weight gain and increases fat loss.

The molecule was recruiting the help of a body's own genes in countering the effects of a high-fat diet. The research team conducting the study believe that their findings may provide a new unexplored therapeutic approach to fighting excessive weight gain in cases where diets or exercise have no effect.

Advertisement


A high-fat diet may contribute to obesity in some individuals. Treatment in such situations has focused on behavioral changes, which is highly challenging to achieve for the general population on a long term basis. This study introduces the concept of recruiting the help of our genes in countering the effects of a high-fat diet, instead of focusing on reducing the intake of high-fat food.

"Dietary management and exercise are not always successful as an intervention for obesity, underscoring the need for efficient medication to treat metabolic disorders," adds Lopez-Herrera, who believes that this treatment represents an as yet unexplored approach to treat obesity.
Advertisement

Researchers know that the structure of some genes that help to produce certain proteins can actually change when someone constantly eats too much high-fat food. In the process, the person can become overweight or obese, or develop other lifestyle-related metabolic disorders such as diabetes or heart problems. In many cases, the same gene can produce two or more alternate proteins, based on how the translation from DNA (gene) to proteins is processed.

One of these genes is lamin A and lamin C (LMNA), which plays a role in the development of different metabolic disorders. The LMNA RNA, which is the genetic material resulting from a process called DNA transcription, is modified by three splicing receptor (SR) proteins called SRSF1, SRSF5 and SRSF6. In this process called splicing, the genetic material encoded in the RNA is basically diced or shifted around and therefore alters the resulting proteins.

The research team found that a small molecule is able to change the way one particular SR protein, SRSFI, works in the bodies of mice that gained excessive weight after being fed a high-fat diet. SRSFI determines which of the gene products of opposing effects could be produced from a single LMNA gene.

One gene product promotes fat storage, the other opposes it. This study showed that blocking SRSF1 with a compound promotes gene expression of the protein that burns calories and prevents fat gain or induces fat loss when mice are on a high-fat diet. It did not have any effect on lean mice of normal weight.

According to the research team, this approach alters the animals' metabolic rate or energy expenditure. It means that it can speed up the metabolism of obese animals, and that their bodies start to function at a higher energy level shedding the excess weight. In the process, their bodies started to burn through much more fat, as especially fatty acids serve as much-needed sources of energy.

"The results of this animal study show that this molecule can abrogate or do away with the effect of a high-fat diet," says Santo. According to Apolit, this compound did not seem to have any adverse effects, so more research in animals and eventual research in humans is needed. If the studies are positive, this may be a new way to treat obesity.

Reference
  1. Santo, J. et al., Pharmacological modulation of LMNA SRSF1-dependent splicing abrogates diet-induced obesity in mice, International Journal of Obesity (2016) http:www.springer.com/gp/about-springer/media/springer-select/obesity--tiny-fat-burning-molecule-might-help-fight-giant-problem/11248370


Source: Medindia

Citations   close

Please use one of the following formats to cite this article in your essay, paper or report:

  • APA

    Julia Samuel. (2016, December 07). New Metabolic Molecule To Control Diet-Induced Obesity. Medindia. Retrieved on May 18, 2022 from https://www.medindia.net/news/healthwatch/new-metabolic-molecule-to-control-diet-induced-obesity-165966-1.htm.

  • MLA

    Julia Samuel. "New Metabolic Molecule To Control Diet-Induced Obesity". Medindia. May 18, 2022. <https://www.medindia.net/news/healthwatch/new-metabolic-molecule-to-control-diet-induced-obesity-165966-1.htm>.

  • Chicago

    Julia Samuel. "New Metabolic Molecule To Control Diet-Induced Obesity". Medindia. https://www.medindia.net/news/healthwatch/new-metabolic-molecule-to-control-diet-induced-obesity-165966-1.htm. (accessed May 18, 2022).

  • Harvard

    Julia Samuel. 2021. New Metabolic Molecule To Control Diet-Induced Obesity. Medindia, viewed May 18, 2022, https://www.medindia.net/news/healthwatch/new-metabolic-molecule-to-control-diet-induced-obesity-165966-1.htm.

Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
What's New on Medindia
World Hypertension Day 2022 - Measure Blood Pressure Accurately, Control It, Live Longer!
Drinking This Popular Beverage May Drop Dementia Risk
Worst Mistakes Parents Make When Talking to Kids
View all
Recommended Reading
News Archive
Date
Category
Advertisement
News Category

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Bariatric Surgery Obesity Bulimia Nervosa Body Mass Index Liposuction Battle of the Bulge Diabesity Hunger Fullness and Weight Control Diet and Nutrition for Healthy Weight Loss Diabetes Type 2 and Its Link to Sugar-Sweetened Beverages 

Most Popular on Medindia

Selfie Addiction Calculator Daily Calorie Requirements Hearing Loss Calculator Diaphragmatic Hernia Blood Donation - Recipients Color Blindness Calculator Loram (2 mg) (Lorazepam) Calculate Ideal Weight for Infants How to Reduce School Bag Weight - Simple Tips Accident and Trauma Care

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2022

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use