About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

New Kidney Biomarker to Signal Lupus

Font : A-A+

Highlights
  • Lupus is a chronic autoimmune disease which affects the joints, skin, heart, kidneys and lungs
  • Scientists explore new kidney biomarkers to track lupus progression and its complications
  • Urinary epidermal growth factor shows promising indication to know lupus severity and progression

New Kidney Biomarker to Signal Lupus

Lupus is a chronic autoimmune disease which affects the skin, joints and other organs. Kidney biomarkers are used to track lupus progression and its complications, finds a study from the University of Michigan.

The research study was presented at the American Society of Nephrology's Kidney Week 2016 meeting.

Advertisement


Emily Somers, Ph.D., Sc.M., associate professor of internal medicine (rheumatology), environmental health sciences and obstetrics and gynecology, University of Michigan, said, "Lupus patients have a high risk of kidney involvement, which can lead to end-stage renal disease requiring dialysis or transplant."

"In addition, there is a great need for biomarkers to detect early kidney involvement and to monitor progression."

Lupus is considered to be a chronic inflammatory disease which occurs when the immune system of the body attacks its own tissues and organs. Lupus can affect the skin, joints, kidneys, heart and lungs.
Advertisement

Somers said, "Lupus is a disease that predominantly affects women, often striking at the prime of life."

The Michigan Lupus Epidemiology and Surveillance (MILES) program includes a biorepository registry (collection of biological materials for further investigation) of 650 lupus patients.

"Through the MILES Program, we previously showed that for black women, who are disproportionately affected by lupus, their risk of lupus is highest in their 20s. Forty percent of black females with lupus have kidney involvement, and 15 percent have end-stage renal disease."

Somers along with Wenjun Ju, Ph.D., associate research scientist and Matthias Kretzier, M.D., Professor of Nephrology, measured the urinary epidermal growth factor in lupus patients.

The researchers have already proved that the urinary epidermal growth factor to be a promising biomarker for estimating kidney disease progression.

Epidermal growth factor is a factor that binds to the receptor and stimulates cell growth, proliferation and differentiation. It is found in urine, saliva, plasma and milk.

The research team found that the decrease in the epidermal growth factor is an indicator of reduced kidney function in chronic kidney disease patients.

The study findings showed that the levels of the urinary epidermal growth factor of 394 lupus patients were able to show improved ability in determining kidney functions when compared to other markers like protein- to- creatinine ratio.

The urinary epidermal growth factor was also able to represent the lupus damage with a global score.

The author concluded that validating the biomarker will help to know lupus severity and progression. This would help to enhance and identify the patients who are affected with lupus and reduce its complications.

Facts on Lupus
  • Lupus is not communicable.
  • Around 5 million people in the world have some form of lupus.
  • Lupus patients have an overactive immune system and is not related to HIV/AIDS.
  • Women of childbearing age (15-44) are commonly affected by lupus.
  • Lupus is more prevalent among African Americans and Asians when compared to Caucasian women.
Signs and Symptoms of Lupus
  • Joint pain, stiffness and swelling
  • Weakness and fever
  • Butterfly - shaped rash on the face
  • Skin lesions due to sun exposure
  • Dry eyes
  • Chest pain
  • Head ache
  • Memory loss
Reference
  1. What is lupus? - ( http://www.lupus.org/answers/entry/what-is-lupus)
  2. Lupus - ( https://medlineplus.gov/lupus.html )


Source: Medindia
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Advertisement
News Category
What's New on Medindia
January is the Thyroid Awareness Month in 2022
Menstrual Disorders
Coffee May Help You Fight Endometrial Cancer
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Urinary Stones In Children Vesico-Ureteric Reflux Causing UTI in Children Hydronephrosis / Antenatal Counseling Kidney Disease Kidney Kidney Health Stones in Urinary Tract Renal Tubular Acidosis Aplastic Anemia Kidney Biopsy 

Recommended Reading
Source of Biomarker Identified for Chronic Kidney Disease
The place of origin of suPAR in the human body had been a mystery until now. SuPAR is not just a .....
Quiz on Lupus
Lupus is a chronic condition that has varied manifestations. Test your knowledge on lupus by ......
Aplastic Anemia
Aplastic anemia (AA) is a term that refers to a condition where the body fails to produce enough blo...
Hydronephrosis / Antenatal Counseling
Currently most pregnant women undergo one or two ultrasound scans during their ......
Renal Tubular Acidosis
Renal tubular acidosis/RTA results in acid content of the blood being higher than normal and that of...
Stones in Urinary Tract
Ask people who have suffered from urinary stones and they will tell you how excruciating the pain ca...
Urinary Stones In Children
There is a wide misconception that only adults develop stones. On the contrary kidney stones are ver...
Vesico-Ureteric Reflux Causing UTI in Children
Bacterial infection of urinary bladder can cause pain and burning sensation while passing urine. Abn...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2022

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use
open close
CONSULT A DOCTOR
I have read and I do accept terms of use - Telemedicine

Advantage Medindia: FREE subscription for 'Personalised Health & Wellness website with consultation' (Value Rs.300/-)