About Careers Internship MedBlog Contact us
Nano-Technology Aids Pancreatic Islet Transplantation

Nano-Technology Aids Pancreatic Islet Transplantation

Font : A-A+

  • Bilirubin-filled nano-capsules could improve survival of transplanted pancreatic cells.
  • This nanoparticle delivery of bilirubin achieves a protective effect in isolated murine islets.
  • Pancreatic islet transplantation is the only noninvasive treatment for type 1 diabetes mellitus.

By encapsulating bilirubin within tiny nanoparticles, a research team at the North Carolina State University and the Ohio State University have improved the survival rates of pancreatic islet cells in vitro in a low-oxygen environment. The work has implications for the treatment of Type 1 diabetes in both canine and human patients.

Bilirubin for pancreatic islet transplantation
Unlike an organ transplant, where the organ is connected directly to blood vessels and has an immediate oxygen supply, transplanted islet cells are simply injected into the recipient's bloodstream and lodge in small veins in the liver, a low-oxygen environment in which up to 70 percent of the transplanted cells die within 72 hours of the procedure.


Chris Adin, currently an associate professor of soft tissue and oncologic surgery at NC State's College of Veterinary Medicine and previously at Ohio State, thought that the answer to saving these transplanted islet cells might lie in a naturally occurring antioxidant - bilirubin. "Bilirubin is a molecule found in every cell in our body," says Adin, "and while too much of it can be harmful, it can be beneficial if we supplement cells with just the right amount of this molecule."

So Adin set out to see if adding bilirubin to the islet cells would increase their transplant survival rates.

Nono-capsules delivers bilirubin to the destined cells
The main obstacle was in delivering the bilirubin to the cells of interest. Since the molecule is not very soluble in water, it couldn't be effectively taken up by the cells if it was simply added to the solution they were in.

Xiaoming He, professor of biomedical engineering at Ohio State, partnered with Adin to design a delivery vehicle for the bilirubin. They came up with a nanocapsule made from Pluronic 127-chitosan that would enclose the bilirubin molecule, be taken up by the islet cell, and release the bilirubin inside the cell.

He and Adin tested their particles in vitro on islet cells that had been grown in culture and exposed to low-oxygen environments. They found that a dose of 5 micromolar bilirubin had the maximum protective benefit while still preserving the islet cells' function. In those treated cells, the low-oxygen death rate was only 18 percent.

Pancreatic islet transplantation
Patients with Type 1 diabetes are unable to produce enough insulin naturally. One treatment for Type 1 diabetes is pancreatic islet transplantation, in which groups of cells from a donor pancreas are transplanted into the patient, where they can sense glucose levels and produce insulin to control diabetes. Islet transplantation is currently the only non-invasive curative treatment for the disease; however, the main drawback is the high rate of cell death after transplantation.

"The cell death rate from islet transplants has been the major roadblock to this procedure's usefulness," says Adin. "These nanocapsules provide a bilirubin delivery method that allows targeted dosing, preserving both the cells and their functionality."

Adin's next steps include creating a treatment program for canine patients which can serve as a model for humans. "There are between 400,000 and 800,000 dogs in the U.S. with Type 1 diabetes," he says. "Figuring out a treatment for dogs will not only alleviate their suffering, but could lead to improved treatments for humans as well."

References :
  1. Bronwyn Fullagar, Wei Rao et al. Nano-Encapsulation of Bilirubin in Pluronic F127-Chitosan Improves Uptake in ƒĀ Cells and Increases Islet Viability and Function after Hypoxic Stress, Cell Transplantation http:dx.doi.org/10.1177/0963689717735112

Source: Eurekalert

Citations   close

Please use one of the following formats to cite this article in your essay, paper or report:

  • APA

    Chrisy Ngilneii. (2017, December 19). Nano-Technology Aids Pancreatic Islet Transplantation. Medindia. Retrieved on Sep 28, 2022 from https://www.medindia.net/news/healthwatch/nano-technology-aids-pancreatic-islet-transplantation-175605-1.htm.

  • MLA

    Chrisy Ngilneii. "Nano-Technology Aids Pancreatic Islet Transplantation". Medindia. Sep 28, 2022. <https://www.medindia.net/news/healthwatch/nano-technology-aids-pancreatic-islet-transplantation-175605-1.htm>.

  • Chicago

    Chrisy Ngilneii. "Nano-Technology Aids Pancreatic Islet Transplantation". Medindia. https://www.medindia.net/news/healthwatch/nano-technology-aids-pancreatic-islet-transplantation-175605-1.htm. (accessed Sep 28, 2022).

  • Harvard

    Chrisy Ngilneii. 2021. Nano-Technology Aids Pancreatic Islet Transplantation. Medindia, viewed Sep 28, 2022, https://www.medindia.net/news/healthwatch/nano-technology-aids-pancreatic-islet-transplantation-175605-1.htm.


News A-Z
What's New on Medindia
Anemia among Indian Women and Children Remains a Cause of Concern- National Family Health Survey-5
H1N1 Influenza Prevention in Children: What Parents Need to Know
Dietary Factors Responsible for Dihydrotestosterone (DHT) Production and Hair Loss
View all
Recommended Reading
News Archive
News Category

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Oral Health And AIDS Pancreatic Cancer AIDS/HIV AIDS/HIV - Epidemiology AIDS/HIV - Clinical Features AIDS/HIV - Health Education AIDS/HIV - Prevention And Transmission AIDS / HIV - Treatment AIDS/HIV- Lab Tests and Faqs AIDS - Initial Theories and Disease Progression 

Most Popular on Medindia

Drug Side Effects Calculator Turmeric Powder - Health Benefits, Uses & Side Effects Iron Intake Calculator Blood Pressure Calculator How to Reduce School Bag Weight - Simple Tips Vent Forte (Theophylline) Drug Interaction Checker Daily Calorie Requirements Loram (2 mg) (Lorazepam) Sinopril (2mg) (Lacidipine)
This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use

Nano-Technology Aids Pancreatic Islet Transplantation Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests