About Careers Internship MedBlog Contact us
Kidney Health of Individuals With Obesity Can be Protected

Kidney Health of Individuals With Obesity Can be Protected

Font : A-A+

  • People with obesity are at greater risk of developing chronic kidney disease due to the structural and functional changes of the kidney
  • A particular cellular receptor (CB1R) in renal proximal tubular cells (RPTCs) causes kidney damage
  • Targeting the receptor (CB1R) can protect individuals with obesity from chronic kidney failure

Obesity leads to kidney damage or renal failure and the mechanism behind this development has been understood, reveals a new study.

The findings of this study appear in an issue of the Journal of the American Society of Nephrology (JASN). The research team points toward a possible target for protecting the health of the kidneys in individuals with obesity.


The structure and function of the kidneys change due to obesity, and this explains why people with obesity are at greater risk of developing chronic kidney disease, and its progression leads to renal failure.

Multiple metabolic factors contributing to obesity-induced kidney problems have been suggested. But the underlying mechanisms behind the development of renal failure are not completely understood.

The study was lead by Joseph Tam, DMD, Ph.D., and Ph.D. student Shiran Udi, MSc from the Institute for Drug Research, The Hebrew University of Jerusalem, Israel.

The research team investigated the kidney cells, which are responsible for the reabsorption of nutrients and allowing other substances that have no nutritional value to be excreted in the urine.

These renal proximal tubular cells (RPTCs) are particularly susceptible to the accumulation of lipids (fat), an effect known as lipotoxicity.

Development of Renal Injury can be Reduced

The role of endocannabinoids, lipid molecules, which act on a particular cellular receptor (CB1R) in RPTC lipotoxicity has been reviewed by the research team.

The mice experienced less obesity-induced lipid accumulation in the kidney, less kidney dysfunction, injury, inflammation, and scarring, especially in those that lacked expression of the receptor in RPTCs.

The molecular signaling pathway revealed by the research team was involved in mediating the CB1R-induced kidney injury and lipotoxicity in RPTCs.

These deleterious effects have been linked to decreased activation of liver kinase B1, the energy sensor AMP-activated protein kinase, and reduced fatty acid β-oxidation, reveals the research team.

Dr. Tam said, "This work provides a novel approach to slow the development of renal injury through chronic blockade of peripheral CB1Rs."

"And, it also supports strategies aimed at reducing the activity of the endocannabinoid system, specifically in the kidney, to attenuate the development of RPTC dysfunction in obesity," explained Dr. Tam.

Link Between Obesity and Kidney Damage

Obesity is a global epidemic that affects more than 600 million people worldwide. It affects multiple body systems and predisposes to various health problems. People who are overweight or obese are at a two-to-seven times increased risk of suffering from end-stage kidney disease.

Besides affecting the kidney directly, obesity can affect the kidneys indirectly through its ability to cause high blood pressure and diabetes. Around a fourth of patients with high blood pressure and around a third of patients with diabetes suffer from kidney disease.

Hence, it is important to prevent obesity to avoid kidney disease. Preventive measures should be adopted early in life, as it may not always be easy to reduce weight quickly.

  1. Shiran Udi, et. al. Proximal Tubular Cannabinoid-1 Receptor Regulates Obesity-Induced CKD. Journal of the American Society of Nephrology (JASN) (2017). DOI: 10.1681/ASN.2016101085

Source: Medindia

Citations   close

Please use one of the following formats to cite this article in your essay, paper or report:

  • APA

    Hannah Joy. (2017, September 01). Kidney Health of Individuals With Obesity Can be Protected. Medindia. Retrieved on Sep 27, 2022 from https://www.medindia.net/news/healthwatch/kidney-health-of-individuals-with-obesity-can-be-protected-172726-1.htm.

  • MLA

    Hannah Joy. "Kidney Health of Individuals With Obesity Can be Protected". Medindia. Sep 27, 2022. <https://www.medindia.net/news/healthwatch/kidney-health-of-individuals-with-obesity-can-be-protected-172726-1.htm>.

  • Chicago

    Hannah Joy. "Kidney Health of Individuals With Obesity Can be Protected". Medindia. https://www.medindia.net/news/healthwatch/kidney-health-of-individuals-with-obesity-can-be-protected-172726-1.htm. (accessed Sep 27, 2022).

  • Harvard

    Hannah Joy. 2021. Kidney Health of Individuals With Obesity Can be Protected. Medindia, viewed Sep 27, 2022, https://www.medindia.net/news/healthwatch/kidney-health-of-individuals-with-obesity-can-be-protected-172726-1.htm.


News A-Z
What's New on Medindia
H1N1 Influenza Prevention in Children: What Parents Need to Know
Dietary Factors Responsible for Dihydrotestosterone (DHT) Production and Hair Loss
Test Your Knowledge About Chromosomes?
View all
Recommended Reading
News Archive
News Category

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Bariatric Surgery Obesity Bulimia Nervosa Urinary Stones In Children Vesico-Ureteric Reflux Causing UTI in Children Hydronephrosis / Antenatal Counseling Body Mass Index Kidney Disease Liposuction Kidney 

Most Popular on Medindia

Sanatogen Nutam (400mg) (Piracetam) Accident and Trauma Care Turmeric Powder - Health Benefits, Uses & Side Effects A-Z Drug Brands in India Calculate Ideal Weight for Infants Drug Interaction Checker The Essence of Yoga Iron Intake Calculator Sinopril (2mg) (Lacidipine)
This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use

Kidney Health of Individuals With Obesity Can be Protected Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests