About Careers MedBlog Contact us
Medindia LOGIN REGISTER
Inner Ear Cell Transplant - Potential Therapy for Hearing Loss
Advertisement

Inner Ear Cell Transplant - Potential Therapy for Hearing Loss

Font : A-A+

Highlights:
  • Inner ear cell transplantation could be a novel therapy for congenital hearing loss.
  • Existing treatments include cochlear implants and hearing aids.
  • Human-derived cell transplantation into the inner ears of embryonic mice compensates for missing protein function.

Human iPS cell-derived inner ear cells that express human-derived proteins have been successfully transplanted into the inner ears of embryonic mice by a Japanese research team.

Hereditary hearing loss accounts for about half of all congenital hearing loss cases, and this work is a major contribution toward research that targets the embryonic inner ear.

Advertisement

Inner Ear Cell Transplant - Potential Therapy for Hearing Loss

Transplantation of inner ear cells into mice
First, the research team succeeded in efficiently inducing inner ear cells expressing inner ear specific proteins, such as CONNEXIN 26, CONNEXIN 30, and PENDRIN, from human iPS cells. They then transplanted progenitors of the inner ear cells into the inner ear of embryonic normal and Connexin 30 knockout mice using glass tubes with optimized tip sizes. The transplanted cells grafted to various sites throughout the inner ear in both groups. However, the Connexin 30 knockout mice had more grafted cells than the normal mice, and some of the grafted cells were found to express CONNEXIN 30.

Potential therapy for genetic hearing loss
The fact that Connexin 30 knockout mice had a higher number of grafted cells than normal mice, and that some of the grafted cells expressed CONNEXIN 30 is a very important finding when considering cell transplantation as a treatment for hereditary hearing loss caused by CONNEXIN deficiency. Cell transplantation can compensate for missing CONNEXIN and may improve hearing loss by adding properly functioning CONNEXIN proteins.
Advertisement

Future work will attempt to increase the number of grafted cells and improve hearing ability. The prevention of hearing loss is an exciting prospect.

Furthermore, this study revealed that cells derived from humans can be grafted into the heterozygous inner ear of mouse embryos. This adds the possibility of in vivo experiments on therapeutic effects using human-derived cells in the mouse embryo. It is thought that this line of research can greatly contribute to the development of a fundamental treatment for hereditary hearing loss and inner ear development research.

Congenital hearing loss
With an incidence frequency of one per 500 to 1,000 newborns, congenital hearing loss is the most frequently occurring congenital disease, and approximately half of all congenital hearing loss cases are hereditary. Treatment for this kind of hearing loss includes cochlear implants and hearing aids, but there is no fundamental therapy.

In human hereditary hearing loss, deafness has already occurred by birth. It is therefore considered that treatment during the fetal stage would be most effective. The GJB6 gene encodes the CONNEXIN 30 protein, which is essential in hearing development, and a deficiency of the gene results in the second most common disease among cases of hereditary hearing loss that have no other disease in the inner ear.

In previous work, Dr. Ryosei Minoda, head of the Department of Otolaryngology at Kumamoto General Hospital, reported that hearing loss was restored by gene therapy to the inner ear of Connexin 30 deficient fetal mice. The current research team, which includes Dr. Minoda and Dr. Hiroki Takeda of Kumamoto University, and several researchers from Keio University, have successfully grafted human iPS-derived cells into the inner ear of embryonic mice, a feat with a high level of technical difficulty.

References :
  1. Hiroki Takeda, Makoto Hosoya et al. Engraftment of Human Pluripotent Stem Cell-derived Progenitors in the Inner Ear of Prenatal Mice, Scientific Reports doi:10.1038/s41598-018-20277-5


Source: Eurekalert

Citations   close

Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
What's New on Medindia
Test  Your Knowledge on Heart
Test Your Knowlege on Genes
Obesity in Teens Make Inroads into Early Atrial Fibrillation
View all
Recommended Reading
News Archive
Date
Category
Advertisement
News Category

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Tinnitus Presbycusis Parkinsons Disease Surgical Treatment Reiki and Pranic Healing Acoustic Neuroma Meniere’s Disease Hearing Aids Hearing Tests in Newborns Hearing Loss Usher Syndrome 

Most Popular on Medindia

Loram (2 mg) (Lorazepam) Noscaphene (Noscapine) Calculate Ideal Weight for Infants Post-Nasal Drip Drug Side Effects Calculator Iron Intake Calculator A-Z Drug Brands in India Turmeric Powder - Health Benefits, Uses & Side Effects Blood Pressure Calculator Blood Donation - Recipients
This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use
×

Inner Ear Cell Transplant - Potential Therapy for Hearing Loss Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests