Billaud and colleagues, from the University of Virginia School of Medicine,
initiated a study in mice and the results have been reported in the
individual grows older, the internal wall of the large intestine becomes thinner
and increasingly elastic and this in turn leads to obesity, metabolic disease,
atherosclerosis and abnormally high BP.
at present, researchers and physicians are engaged in measuring arterial
compliance of the large arteries (as a means to evaluate arterial stiffness)
during the advanced stages of a health condition, it is not expected to provide
adequate information about the initiation or progress of the disease.
studies have indicated that changes in the walls of small arteries are the most
potent indicators of CVD and, early detection of these changes is important in
the treatment and management of the condition.
and colleagues, as part of their research, compared the arterial compliance of
two arteries of different sizes-the carotid artery (large) and thoracodorsal
artery (smaller)- in mice.
were divided into two groups. One of the groups was given high -fat diet for
six weeks and the other, which formed the control group, was fed a normal diet.
scientists observed rapid changes in the structural and mechanical properties
of the small arteries in mice that were fed for six months on high-fat diet.
scientists conclusively state, "These results suggest that, at an early
stage of obesity, the structural properties of small and large arteries are
altered whereas arterial stiffness is only observed in small vessels."
studies have shown that in humans the adipose cells surrounding the coronary
arteries tend to become highly inflamed and this, in turn, could cause
inflammation in the blood cells surrounding the arteries. When mice were fed
with high-fat diet the inflammation of the fat tissues around the arteries
remains that inflammation of the adipose tissues around arteries is an important
event in atherosclerosis, and that the lipid or cholesterol levels in these
patients can appear normal.
therefore cautions us to go easy on high -fat diet and prompts us to adopt
regular exercise to stay fit. After all, a healthy heart not only prolongs life
but also adds quality to one's years...!