- Women who drink moderate to heavy amounts may change their babies' genes
- Changes to two genes were found: POMC, that involves the stress-response system, and PER2, that monitors the body's biological clock
- The babies also had high levels of cortisol, a stress hormone, that suppresses the immune system and had other health problems
- There is no known safe amount of alcohol to drink while pregnant. Abstinence is the key
Mothers who drink moderate to high levels of alcohol during pregnancy may be changing their babies' DNA, according to a Rutgers-led study.
Study on the Impact of Prenatal Alcohol Exposure
The study by Sarkar and scientists in a Collaborative Initiative on Fetal Alcohol Spectrum Disorders is in the journal Alcoholism: Clinical and Experimental Research.
Building on an earlier Rutgers-led study that found binge and heavy drinking may trigger long-lasting genetic change in adults, the researchers sought alcohol-induced DNA changes in 30 pregnant women and 359 children.
They found changes to two genes - POMC, which regulates the stress-response system, and PER2, which influences the body's biological clock - in women who drank moderate to high levels of alcohol during pregnancy and in children who had been exposed to those levels of alcohol in the womb.
What is Heavy and Moderate Drinking?
Heavy drinking in women is four or more drinks on at least five occasions in a month. Moderate drinking in women is about three drinks per occasion.
"Our research may help scientists identify biomarkers - measurable indicators such as altered genes or proteins - that predict the risks from prenatal alcohol exposure," Sarkar said.
Fetal Alcohol Spectrum Disorders
Fetal alcohol spectrum disorders can include physical or intellectual disabilities as well as behavioral and learning problems. While there is no cure, early intervention treatment services can improve a child's development, according to the U.S. Centers for Disease Control and Prevention, which says there is no known safe amount of alcohol to drink while pregnant.
Alcohol and Cortisol
The study also found that infants exposed to alcohol in the womb - which passes from the mother's blood through the umbilical cord - had increased levels of cortisol, a potentially harmful stress hormone that can suppress the immune system and lead to ongoing health issues.
- Moderate to Heavy Drinking During Pregnancy Alters Genes in Newborns, Mothers - (https://news.rutgers.edu/moderate-heavy-drinking-during-pregnancy-alters-genes-newborns-mothers/20190815#.XVZO1-gzbct)
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