About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Diabetes and Heat Disease Risk Increased Due to Improper Fat Storage

Font : A-A+

Diabetes and Heat Disease Risk Increased Due to Improper Fat Storage

Highlights

  • Overeating and physical inactivity results in obesity and related consequences like diabetes and heart diseases.
  • When the body becomes resistant to insulin, levels of blood sugars and lipids rise, increasing the risk of diabetes and heart disease.
  • Study points to 53 regions of the genome associated with insulin resistance and higher risk of diabetes and heart disease.
  • A greater number of the 53 genetic variants for insulin resistance was associated with having lower amounts of fat under the skin, particularly peripherally.
  • The failure to safely store excess fat in the body, which is one of the key adverse consequence of obesity, results in the development of insulin resistance - a risk factor for type 2 diabetes and heart attacks.

    Overeating and being physically inactive leads to excess energy, which is stored as fat tissue.

Advertisement


This leads to rising levels of obesity and a global epidemic of diseases such as heart disease, stroke and type 2 diabetes.

A key process in the development of these diseases is the progressive resistance of the body to the actions of insulin, a hormone that controls the levels of blood sugar.
Advertisement

When the body becomes resistant to insulin, levels of blood sugars and lipids rise, increasing the risk of diabetes and heart disease.

However, it is not clear in most cases how insulin resistance arises and why some people become resistant, particularly when overweight, while others do not.

Genomes associated with insulin resistance

An international team led by researchers at the University of Cambridge studied over two million genetic variants in almost 200,000 people to look for links to insulin resistance.

The researches report 53 regions of the genome associated with insulin resistance and higher risk of diabetes and heart disease.

Only 10 of these regions have previously been linked to insulin resistance.

The researchers then carried out a follow-up study with over 12,000 participants in the Fenland and EPIC-Norfolk studies, each of whom underwent a body scan that shows fat deposits in different regions of the body.

They found that having a greater number of the 53 genetic variants for insulin resistance was associated with having lower amounts of fat under the skin, particularly in the lower half of the body.

The team also found a link between having a higher number of the 53 genetic risk variants and a severe form of insulin resistance characterized by loss of fat tissue in the arms and legs, known as familial partial lipodystrophy type 1.

Patients with lipodystrophy are unable to adequately develop fat tissue when eating too much, and often develop diabetes and heart disease as a result.

In follow-up experiments in mouse cells, the researchers were also able to show that suppression of several of the identified genes (including CCDC92, DNAH10 and L3MBTL3) results in an impaired ability to develop mature fat cells.

"Our study provides compelling evidence that a genetically-determined inability to store fat under the skin in the lower half of the body is linked to a higher risk of conditions such as diabetes and heart disease," says Dr Luca Lotta from the Medical Research Council (MRC) Epidemiology Unit at the University of Cambridge.

The results highlight the important biological role of peripheral fat tissue as a deposit of the surplus of energy due to overeating and lack of physical exercise.

This new study suggests thatamong individuals who have similar levels of eating and physical exercise, those who are less able store the surplus energy as fat in the peripheral body, such as the legs, are at a higher risk of developing insulin resistance, diabetes and cardiovascular disease than those who are able to do so.

These new findings may lead to future improvements in the way we prevent and treat insulin resistance and its complications.

The researchers are now collaborating with other academic as well as industry partners with the aim of finding drugs that may reduce the risk of diabetes and heart attack by targeting the identified pathways.

The large-scale genetic study is published in Nature Genetics.



Source: Medindia
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Advertisement
News Category
What's New on Medindia
Cervical Cancer Awareness Month 2022
Ultra-Low-Fat Diet
Goji Berries May Protect Against Age-Related Vision Loss
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Diabetic Retinopathy Cholesterol Diabetes Diabetic Diet Diabetes - Essentials Diabetes - Self-Monitoring of Blood Glucose (SMBG) Insulin Delivery Devices Diabetes and Exercise Diet Lifestyle and Heart Disease Stress Relief Through Alternative Medicine 

Recommended Reading
Carbohydrates and Its Role in Obesity
Obesity is a global epidemic with majority of the world's population in developed countries being .....
Top Ten Tips for Children on Insulin for Type 1 Diabetes During Their Summer Break
During summer break it is important for parents and children with type 1 diabetes to stick to an ......
Excess Insulin Secretion After a Meal Causes Reactive Hypoglycemia
Postprandial hypoglycemia occurs when too much insulin is produced and released by the pancreas ......
Keep Diabetes on Check to Avoid Visual Impairments
High blood sugar from diabetes is associated with damage to the tiny blood vessels in the retina, .....
Cholesterol
Cholesterol is produced by the body (liver) and is essential for normal body functioning....
Diabetes
A comprehensive article on diabetes - both Type 1 and Type 2 diabetes, including : causes, signs, sy...
Diabetes - Essentials
Diabetes is a metabolic disease caused by insulin deficiency that leads to high blood sugar levels a...
Diabetes - Self-Monitoring of Blood Glucose (SMBG)
Self-Monitoring Of Blood Glucose (SMBG) is one of the greatest advancements in the management of Di...
Diabetes and Exercise
Regular exercise especially in type II diabetes not only helps reduce the sugar but also reduces the...
Diabetic Diet
The diabetic diet most often recommended is high in dietary fiber (especially soluble fiber) and nut...
Diabetic Retinopathy
The term ‘diabetic retinopathy’ refers to changes in the retina which often occur in people with ......
Insulin Delivery Devices
Insulin delivery devices have evolved drastically since their invention in 1922. They are all aimed ...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2022

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use
open close
ASK A DOCTOR ONLINE
I have read and I do accept terms of use - Telemedicine

Advantage Medindia: FREE subscription for 'Personalised Health & Wellness website with consultation' (Value Rs.300/-)