About Careers Internship MedBlog Contact us
Medindia LOGIN REGISTER
Advertisement

Depression Drug Duloxetine Reduces Joint Pain in Postmenopausal Women With Early Stage Breast Cancer

Font : A-A+

Highlights
  • Aromatase inhibitor (AI) therapy is given to post-menopausal women to stop estrogen production and starve breast cancer cells.
  • Postmenopausal women experience significant pain as a side effect of AI therapy.
  • Depression drug duloxetine helps reduce pain in these women

Depression Drug Duloxetine Reduces Joint Pain in Postmenopausal Women With Early Stage Breast Cancer

Duloxetine drug used to treat depression and anxiety can help lower joint pain in postmenopausal women who are being treated for early-stage breast cancer.

Investigators from SWOG, the international cancer clinical trials network funded by the National Cancer Institute (NCI), conducted a randomized, placebo-controlled trial to test the effectiveness of duloxetine in alleviating joint pain.

Advertisement


The clinical trial called S1202 was led by Dr. N. Lynn Henry. A SWOG investigator from Huntsman Cancer Institute at the University of Utah and co-chair of SWOG's symptom control and quality of life committee.

Each year postmenopausal women are being treated with aromatase inhibitors (AIs), drugs to stop estrogen production and essentially starve hormone receptor-positive breast cancer cells. 50% of the women experience joint pain and stiffness as side effect of AI therapy. The pain associated with the AI therapy is so common and has a name: AI-Associated Musculoskeletal Syndrome (AIMSS).
Advertisement

Henry wanted to conduct a research to address the common problem faced by women with breast cancer.

"A lot of 60-year-old women report feeling like they're 80," Henry said. "The pain can really interfere with daily life. And this is a big problem. The length of treatment with AIs can be five to 10 years, so we're asking a lot of women to manage significant discomfort for a very long period of time."

The initial clinical trial results revealed that acupuncture and exercise were found to reduce symptoms of AIMSS but there is no evidence for an effective solution for all women. So Henry wanted to study the effect of duloxetine on relieving AIMSS symptoms.

299 adult patients were enrolled to S1202 at 43 institutions throughout the NCI's National Cancer Trials Network (NCTN) and the NCI Community Oncology Research Program (NCORP). The patients were divided into two groups

Group I received duloxetine
Group II on placebo

The duration of medication dose was for 12 weeks.

During this period the participants were asked to fill out a questionnaire upon enrolling and again at two, six, 12 and 24 weeks into the study. The questionnaire focused on pain, rated on a 0-10 scale, and also on depression and quality of life.

Study Results

Patients on duloxetine saw their average pain drop on the scale from 5.5 to about 3. In these patients the improvement was rapid, and relief persisted through the end of the 12-week trial.

"We've shown that this treatment is a potential option for women," Dr. Henry said. "Taking this drug may help them tolerate their breast cancer treatment. And it's important for their health that they stick with their treatment."

The new SWOG research is presented at a special plenary presentation at the San Antonio Breast Cancer Symposium.

Duloxetine

Duloxetine belongs to the class of selective serotonin and norepinephrine reuptake inhibitors. The drug works by increasing the levels of serotonin and norepinephrine. Serotonin and norepinephrine are the natural substances in the brain that help maintain mental balance and halt the movement of pain signals in the brain.

Duloxetine sold as Cymbalta is used to treat
  • Depression and generalized anxiety disorder (GAD)
  • Pain and tingling caused by diabetic neuropathy
  • Fibromyalgia
Source: Medindia

Citations   close

Please use one of the following formats to cite this article in your essay, paper or report:

  • APA

    Sheela Philomena. (2016, December 09). Depression Drug Duloxetine Reduces Joint Pain in Postmenopausal Women With Early Stage Breast Cancer. Medindia. Retrieved on Sep 26, 2022 from https://www.medindia.net/news/healthwatch/depression-drug-duloxetine-reduces-joint-pain-in-postmenopausal-women-with-early-stage-breast-cancer-166040-1.htm.

  • MLA

    Sheela Philomena. "Depression Drug Duloxetine Reduces Joint Pain in Postmenopausal Women With Early Stage Breast Cancer". Medindia. Sep 26, 2022. <https://www.medindia.net/news/healthwatch/depression-drug-duloxetine-reduces-joint-pain-in-postmenopausal-women-with-early-stage-breast-cancer-166040-1.htm>.

  • Chicago

    Sheela Philomena. "Depression Drug Duloxetine Reduces Joint Pain in Postmenopausal Women With Early Stage Breast Cancer". Medindia. https://www.medindia.net/news/healthwatch/depression-drug-duloxetine-reduces-joint-pain-in-postmenopausal-women-with-early-stage-breast-cancer-166040-1.htm. (accessed Sep 26, 2022).

  • Harvard

    Sheela Philomena. 2021. Depression Drug Duloxetine Reduces Joint Pain in Postmenopausal Women With Early Stage Breast Cancer. Medindia, viewed Sep 26, 2022, https://www.medindia.net/news/healthwatch/depression-drug-duloxetine-reduces-joint-pain-in-postmenopausal-women-with-early-stage-breast-cancer-166040-1.htm.

Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
What's New on Medindia
H1N1 Influenza Prevention in Children: What Parents Need to Know
Dietary Factors Responsible for Dihydrotestosterone (DHT) Production and Hair Loss
Test Your Knowledge About Chromosomes?
View all
Recommended Reading
News Archive
Date
Category
Advertisement
News Category

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Women and Cancer Adolescence Depression Drug Toxicity Breast Biopsy Depression Pagets disease of the breast Mastitis Menopause Cancer and Homeopathy Ganglion Cysts - Ganglion Wrist 

Most Popular on Medindia

The Essence of Yoga Diaphragmatic Hernia Indian Medical Journals Daily Calorie Requirements Sanatogen Selfie Addiction Calculator Noscaphene (Noscapine) Find a Doctor A-Z Drug Brands in India Hearing Loss Calculator
This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use
×

Depression Drug Duloxetine Reduces Joint Pain in Postmenopausal Women With Early Stage Breast Cancer Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests