About Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Chemotherapy Resistance Cause Identified

Font : A-A+

Highlights
  • Chemotherapy is the use of medicines or drugs to treat cancer.
  • Main problem of chemotherapy is the emergence of resistance against anti-tumor drugs.
  • This is due to the loss of a molecule called TP53TG1, whose function in healthy cells is to prevent activation of YBX1 protein.
  • In the absence of TP53TG1, the YBX1 protein causes activation of hundreds of oncogenes that triggers chemo-resistance.

Chemotherapy Resistance Cause Identified

The cause of multiple resistance in cancer chemotherapy has been identified by researchers in a new study.

Study was conducted by researchers at the Bellvitge Biomedical Research Institute (IDIBELL). The work is published in the Proceedings of the National Academy of Sciences (PNAS).

Advertisement


The lead researcher is Dr. Manel Esteller, Director of Epigenetics and Cancer Biology Program (PEBC) of IDIBELL, ICREA Researcher and Professor of Genetics at the University of Barcelona.

Chemotherapy (chemo) usually refers to the use of medicines or drugs to treat cancer. chemo can kill cancer cells that have spread (metastasized) to parts of the body far away from the original (primary) tumor.
Advertisement

The three main goals of chemotherapy are cure, control and palliation.

The introduction of cancer chemotherapy was a revolution for the treatment of this disease in those cases in which the cure is no longer possible only with the mere extirpation of the tumor.

Chemotherapy has been shown to be effective in a wide range of patients, but one of its main problems is the emergence of resistance against the anti-tumor drug used.

But there are tumors that display cross-resistance against different drugs since its inception, when they have not yet been treated.

"We have found that 10% of colon and stomach tumors present the loss of a molecule called TP53TG1, whose function in healthy cells is to prevent activation of YBX1 protein." says Dr. Manel Esteller.

Without surveillance of TP53TG1 in these gastrointestinal tumors, YBX1 goes to the nucleus of the cell and is responsible for the activation of hundreds of oncogenes that will prevent the death of malignant cells that antitumor drugs induce.

The spectrum of resistances induced by this mechanism is extensive and includes not only drugs commonly used in the treatment of these cancers, such as as 5-fluorouracil, oxyplatinum or irinotecan, but also drugs targeting recent molecular targets such as kinase inhibitors.

The next step would be to study if there is any drug that escapes this mechanism of multiple chemoresistance and also to explore whether restoring the activity of the molecule TP53TG1 would help in regaining the sensitivity of these tumors to the drugs analyzed, which would represent a clinical benefit for these patients.

References
  1. Chemotherapy - (http://www.cancer.org/treatment/treatmentsandsideeffects/treatmenttypes/chemotherapy/chemotherapy-landing)
Source: Medindia

Citations   close

Please use one of the following formats to cite this article in your essay, paper or report:

  • APA

    Dr. Meenakshy Varier. (2016, November 08). Chemotherapy Resistance Cause Identified. Medindia. Retrieved on May 18, 2022 from https://www.medindia.net/news/healthwatch/chemotherapy-resistance-cause-identified-165028-1.htm.

  • MLA

    Dr. Meenakshy Varier. "Chemotherapy Resistance Cause Identified". Medindia. May 18, 2022. <https://www.medindia.net/news/healthwatch/chemotherapy-resistance-cause-identified-165028-1.htm>.

  • Chicago

    Dr. Meenakshy Varier. "Chemotherapy Resistance Cause Identified". Medindia. https://www.medindia.net/news/healthwatch/chemotherapy-resistance-cause-identified-165028-1.htm. (accessed May 18, 2022).

  • Harvard

    Dr. Meenakshy Varier. 2021. Chemotherapy Resistance Cause Identified. Medindia, viewed May 18, 2022, https://www.medindia.net/news/healthwatch/chemotherapy-resistance-cause-identified-165028-1.htm.

Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
What's New on Medindia
World Hypertension Day 2022 - Measure Blood Pressure Accurately, Control It, Live Longer!
Drinking This Popular Beverage May Drop Dementia Risk
Worst Mistakes Parents Make When Talking to Kids
View all
Recommended Reading
News Archive
Date
Category
Advertisement
News Category

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Chronic Lymphocytic Leukemia Hodgkins Lymphoma Non-Hodgkins Lymphoma Chemotherapy Chemotherapy Drugs Peritoneal Cancer Rhabdomyosarcoma Male Breast Cancer Tumor Lysis Syndrome Neutropenic Sepsis 

Most Popular on Medindia

Turmeric Powder - Health Benefits, Uses & Side Effects The Essence of Yoga Drug - Food Interactions Accident and Trauma Care Indian Medical Journals Sinopril (2mg) (Lacidipine) Post-Nasal Drip Selfie Addiction Calculator Nutam (400mg) (Piracetam) Blood Donation - Recipients

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2022

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use