About Careers Internship MedBlogs Contact us
Cabozantinib may Treat Resistant Form of Thyroid Cancer

Cabozantinib may Treat Resistant Form of Thyroid Cancer

Font : A-A+

  • Cabozantinib drug could be a new firstline therapy for metastatic, radioactive iodine-resistant thyroid cancer.
  • Radioactive iodine therapy is the standardized treatment for thyroid cancer but nearly 15 percent of these patients have cancers that are resistant to the therapy.
  • After taking the drug, tumor size decreased by more than 30 percent in 34 patients out of 35.

Cabozantinib may now help treat metastatic; radioactive iodine-resistant thyroid cancer, finds a new study. The findings of this study will be presented at the 2018 Multidisciplinary Head and Neck Cancers Symposium in Arizona.

Tumors shrunk in about 34 out of 35 patients who took the drug, and more than half of those patients saw the tumor size decrease by more than 30 percent.


Most cases of differentiated thyroid cancer are treated with radioactive iodine therapy. Since the thyroid absorbs nearly all of the iodine in the human body, radioactive iodine given to a patient will concentrate in thyroid cancer cells, killing them with little effect on the rest of the body.

The treatment can be curative, but about 15 percent of these patients have cancers that are resistant to the therapy. There are currently two approved treatments in these cases, both of which are kinase inhibitors - drugs that block enzymes that are crucial to a cancer cell's ability to function. However, responses to these treatments are not durable. Once patients progress, they need additional therapeutic options.

"Our trial shows that cabozantinib is an active agent for patients with RAI-refractory thyroid cancer and may be able to significantly improve the care of patients who are at this advanced stage of their disease," said the study's lead author Marcia S. Brose, MD PhD, an associate professor of Otorhinolaryngology: Head and Neck Surgery and director of the Center for Rare Cancers and Personalized Therapy at Penn.

As part of a phase II trial, Brose and her team gave the drug as a first line therapy to 35 patients with metastatic, radioactive iodine-resistant thyroid cancer starting in March of 2014. Thirty-four experienced tumor shrinkage and 19 of the 35 (54 percent) achieved a partial response - defined as a shrinkage greater than 30 percent.

The median time on the study was 35 weeks (range 3-197), and 16 patients are currently still enrolled. "These results indicate cabozantinib may offer an additional treatment option to these patients that will shrink tumors and provide an additional progression-free period for our patients," Brose said.

Twenty-three of the 35 patients (66 percent) required dose interruptions and dose adjustments during the trial. The most common toxicities attributable to cabozantinib included hyperglycemia, which presented in 28 patients (80 percent). Twenty-seven patients experienced diarrhea (77 percent), 26 had fatigue (74 percent), and 25 had weight loss (71 percent). Five patients experienced grade 3-5 hypertension (14 percent), 3 had grade 3-5 increase lipase (9 percent), 2 had grade 3-5 weight loss (6 percent), 2 had grade 3-5 pulmonary embolism (6 percent), and 2 had hyponatremia (6 percent).

Brose says the data show the need for a larger, multi-center study, plans for which are already underway.

Source: Eurekalert

Citations   close

Please use one of the following formats to cite this article in your essay, paper or report:

  • APA

    Rishika Gupta. (2018, February 14). Cabozantinib may Treat Resistant Form of Thyroid Cancer. Medindia. Retrieved on May 26, 2022 from https://www.medindia.net/news/healthwatch/cabozantinib-may-treat-resistant-form-of-thyroid-cancer-177004-1.htm.

  • MLA

    Rishika Gupta. "Cabozantinib may Treat Resistant Form of Thyroid Cancer". Medindia. May 26, 2022. <https://www.medindia.net/news/healthwatch/cabozantinib-may-treat-resistant-form-of-thyroid-cancer-177004-1.htm>.

  • Chicago

    Rishika Gupta. "Cabozantinib may Treat Resistant Form of Thyroid Cancer". Medindia. https://www.medindia.net/news/healthwatch/cabozantinib-may-treat-resistant-form-of-thyroid-cancer-177004-1.htm. (accessed May 26, 2022).

  • Harvard

    Rishika Gupta. 2021. Cabozantinib may Treat Resistant Form of Thyroid Cancer. Medindia, viewed May 26, 2022, https://www.medindia.net/news/healthwatch/cabozantinib-may-treat-resistant-form-of-thyroid-cancer-177004-1.htm.


News A-Z
What's New on Medindia
Monkeypox Outbreak: What it is, How Does it Spread & the Prevention
Seasonal Allergy Medications
How to Choose the Best Eczema-Friendly Moisturizer for Children?
View all
Recommended Reading
News Archive
News Category

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Iodine Deficiency Disorder Hyperthyroidism Hypothyroidism Cancer and Homeopathy Cancer Facts Cancer Tattoos A Body Art Thyroid Cancer Radiation Hazards Common Lifestyle Habits that Cause Diseases 

Most Popular on Medindia

Find a Hospital Post-Nasal Drip How to Reduce School Bag Weight - Simple Tips Nutam (400mg) (Piracetam) Turmeric Powder - Health Benefits, Uses & Side Effects Vent Forte (Theophylline) Blood Pressure Calculator Drug Side Effects Calculator Selfie Addiction Calculator Sinopril (2mg) (Lacidipine)

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2022

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use