About Careers Internship MedBlog Contact us

Sweetener Aspartame Ineffective To Promote Weight Loss

Font : A-A+

  • Aspartame is an artificial sugar substitute found in certain foods and beverages.
  • Sugar substitute may not promote weight loss.
  • Aspartame was found to increase blood sugar levels and inflammatory proteins.

Sweetener Aspartame Ineffective To Promote Weight Loss

Sugar substitute aspartame may not promote weight loss, reveals a study from Massachusetts General Hospital.

The study report was published online in Applied Physiology, Nutrition, and Metabolism.


The research team finds how phenyl alanine (a breakdown product of aspartame) interferes with the activity of the enzyme that prevents metabolic syndrome.

The research study conducted on mice which have received aspartame in their drinking water was found to gain more weight and develop other metabolic syndrome symptoms when compared to other animals which did not take any aspartame.

Richard Hodin, MD, of the MGH Department of Surgery, said that "Sugar substitutes like aspartame are designed to promote weight loss and decrease the incidence of metabolic syndrome, but some clinical and epidemiologic studies have suggested that these products don't work very well and may actually make things worse."

"We found that aspartame blocks a gut enzyme called intestinal alkaline phosphatase (IAP) that we previously showed can prevent obesity, diabetes, and metabolic syndrome; so we think that aspartame might not work because, even as it is substituting for sugar, it blocks the beneficial aspects of IAP." he added.

The previous study published in the Proceedings of the National Academy of Sciences in 2013 showed intestinal alkaline phosphatase enzyme fed mice on high - fat diet was found to reduce symptoms and prevent metabolic syndrome.

Phenylalanine which is produced from aspartame was found to inhibit the action of the intestinal alkaline phosphatase enzyme and this led to the investigation of the inhibitory properties of aspartame for lack of weight-loss effect.

Intestinal alkaline phosphate enzyme is produced in the small intestine. By conducting some experiments, the research team found the activity of the enzyme to be reduced when it was added to a solution containing aspartame sweetened soft drink compared to a sugar containing beverage.

Four groups of mice were taken for the study, out of which two groups took normal diet in which one received aspartame drinking water and the other received plain water. The remaining two groups received high-fat diet similarly one with aspartame and other with plain water.

The study results found animals fed with normal diet and which received aspartame to have consumed an amount equivalent to three and half cans of diet soda daily and the group which received high-fat diet consumed an equivalent of about two cans.

There was only a little difference between weights of the animals in the two groups with normal diet and animals on high-fat diet who received aspartame gained more weight than those that received plain water.

In both the groups, aspartame received mice were found to have high blood sugar levels and higher levels of inflammatory protein TNFĢ\ in their blood.

Hodin, professor of surgery at Harvard Medical School said that "People do not really understand why these artificial sweeteners don't work. There has been some evidence that they actually can make you more hungry and may be associated with increased calorie consumption. Our findings regarding aspartame's inhibition of IAP may help explain why the use of aspartame is counterproductive."

"While we can't rule out other contributing mechanisms, our experiments clearly show that aspartame blocks IAP activity, independent of other effects." he added.

Source: Medindia

Citations   close

Please use one of the following formats to cite this article in your essay, paper or report:

  • APA

    Madhumathi Palaniappan. (2016, November 24). Sweetener Aspartame Ineffective To Promote Weight Loss. Medindia. Retrieved on Sep 28, 2022 from https://www.medindia.net/news/healthwatch/aspartame-ineffective-to-promote-weight-loss-165561-1.htm.

  • MLA

    Madhumathi Palaniappan. "Sweetener Aspartame Ineffective To Promote Weight Loss". Medindia. Sep 28, 2022. <https://www.medindia.net/news/healthwatch/aspartame-ineffective-to-promote-weight-loss-165561-1.htm>.

  • Chicago

    Madhumathi Palaniappan. "Sweetener Aspartame Ineffective To Promote Weight Loss". Medindia. https://www.medindia.net/news/healthwatch/aspartame-ineffective-to-promote-weight-loss-165561-1.htm. (accessed Sep 28, 2022).

  • Harvard

    Madhumathi Palaniappan. 2021. Sweetener Aspartame Ineffective To Promote Weight Loss. Medindia, viewed Sep 28, 2022, https://www.medindia.net/news/healthwatch/aspartame-ineffective-to-promote-weight-loss-165561-1.htm.


News A-Z
What's New on Medindia
World Heart Day in 2022- Use Heart for Every Heart
Anemia among Indian Women and Children Remains a Cause of Concern- National Family Health Survey-5
H1N1 Influenza Prevention in Children: What Parents Need to Know
View all
Recommended Reading
News Archive
News Category

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Diet Pills Obesity The Cabbage Diet Zone Diet Mediterranean Diet Bulimia Nervosa The Macrobiotic Diet Height and Weight-Kids Body Mass Index Weight Loss Program For Men 

Most Popular on Medindia

Noscaphene (Noscapine) Iron Intake Calculator Sanatogen Blood Pressure Calculator Drug Interaction Checker Post-Nasal Drip Selfie Addiction Calculator Blood Donation - Recipients Loram (2 mg) (Lorazepam) Sinopril (2mg) (Lacidipine)
This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use

Sweetener Aspartame Ineffective To Promote Weight Loss Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests