The authors of the study hoped to find out why certain children have frequent throat infections and complications, a question that has puzzled scientists for a long time.
The findings of the study, therefore, suggest that a combination of immunological and genetic factors may be responsible for recurrent tonsillitis (RT) or throat infections in some children.
The authors of the study feel that the findings of the study could pave the way for research in the development of vaccines to prevent throat infections which could help to avoid invasive surgeries, costly and costly antibiotics with potential side effects and the huge burden on the health care system.
Shane Crotty, senior author, Ph.D., a professor in the Division of Vaccine Discovery said: "
We have 100+ years of experience with this disease but there really wasn't any good explanation why some kids suffer from recurrent strep throat. We think that this is the first solid evidence that there is an important immunological component as well as a genetic one which together contributes to recurrent strep throat. Let's try and build on it." What is Streptococcal Throat Infection?
Streptococcal throat infection is one of several infections caused by the bacterium
Streptococcus pyogenes, also referred to as group A Streptococcus (GAS). Other serious infections include pneumonia,
impetigo,
scarlet fever and necrotizing fasciitis, the feared flesh-eating disease.
Streptococcal throat infection is easily treated with antibiotics but recurrent infections can be troublesome. Also, undiagnosed or untreated streptococcal throat infections can lead to serious complications later including damage to the heart and
rheumatic heart disease.
Summary
Recurrent streptococcal throat infections in some children are due to a combination of immunological and genetic factors. It can result in serious late complications including heart damage. Development of an effective vaccine could potentially prevent recurrent streptococcal throat infections and associated complications.
References :- Recurrent group A Streptococcus tonsillitis is an immunosusceptibility disease involving antibody deficiency and aberrant TFH cells - (http://stm.sciencemag.org/content/11/478/eaau3776)
- Why your kid's strep throat keeps coming back - (http://dx.doi.org/10.1126/scitranslmed.eaau3776)
Source: Medindia