About Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Whole Foods Lower Risk of Colon Cancer
Advertisement

Whole Foods Lower Risk of Colon Cancer

Font : A-A+

Highlights:

  • Whole foods could be a better way to prevent low-grade chronic inflammation and colon cancer
  • Whole foods reduced the levels of colonic mucosal interleukin-6 (IL-6), which is linked to colon cancer
  • Common whole foods are whole grains, tubers, fruits and vegetables.

A diet rich in colorful fruits and vegetables may contain compounds that can reduce the risk of developing colon cancer and inflammatory bowel disease, finds a new study.

High-calorie Diet Increase Risk of Colon Cancer

A high-calorie diet increases the risk of colon cancer by elevating colonic mucosal interleukin-6 (IL-6) expression, which plays a role in inflammation. Elevated levels of IL-6 are correlated with proteins, such as Ki-67, which is linked to the spread and growth of cancer cells.

Whole Foods Lower Colon Cancer Risk

A research team from the Pennsylvania State University conducted a study on pigs. Pigs in the experimental group were served a high-calorie diet supplemented with purple-fleshed potatoes. Pigs in the control group were also served a high-calorie diet.

Pigs that were fed purple-fleshed potatoes had less colonic mucosal IL-6 compared to the control group.

Advertisement


Whole foods contain phytonutrients such as carotenoids and flavonoids that are effective in altering the IL-6 pathway.

Colorful fruits and vegetables could prompt similar effects, but the research team used purple potatoes that contain high amounts of bioactive compounds, such as anthocyanins and phenolic compounds. These bioactive compounds have been linked to cancer prevention.
Advertisement

White potatoes also have beneficial compounds, but purple potatoes have greater concentrations of anti-inflammatory and antioxidant compounds.

The research team used both uncooked and baked purple potatoes and found similar effects. Currently, anti-IL-6 drugs are used to treat rheumatoid arthritis and are being considered to treat other inflammation-promoted diseases like colon cancer. But anti-IL-6 drugs are expensive and can cause side-effects.

"The pig model was used because the digestive system is very similar to the human digestive system, more so than in mice. However, the diet approach to cancer treatment has also shown similar promise in mice," said Vanamala.

The research team hopes to conduct further research to understand how bioactive compounds work on a molecular level. This could be an initial step toward finding treatments for people with cancer.

The findings of the study are published in the Journal of Nutritional Biochemistry.

The study adds evidence to recent researches that suggest that plant-based diet tend to lower colon cancer rates than meat-based diets.

Whole Foods

Whole foods are plant foods that are unprocessed and unrefined before being consumed like whole grains, tubers, legumes, fruits, and vegetables. Whole foods contain macronutrients (protein), micronutrients (vitamins and minerals) and phytonutrients (carotenoids and flavonoids).

"What we are learning is that food is a double-edged sword -- it may promote disease, but it may also help prevent chronic diseases, like colon cancer. But, what we don't know is, 'how does this food work on the molecular level?' This study is a step in that direction," said Jairam K.P. Vanamala, associate professor of food sciences, Penn State.

Colon Cancer

Colon cancer is the cancer of the large intestine, the lower part of the digestive system. In most of the cases, colon cancer begins as small noncancerous clumps called adenomatous polyps. People with colon cancer usually do not experience symptoms in the early stages. Some of the symptoms and signs of colon cancer are constipation, rectal bleeding, abdominal discomfort, fatigue, weight loss, and diarrhea. A diet low in fiber and high in fat contributes to the development of colon cancer. Studies have shown that people who follow a diet high in red meat and processed meat are at an increased risk of colon cancer.

Tips to Prevent Cancer

  • Maintain a healthy weight
  • Avoid calorie-dense foods like deep fried and junk foods
  • Include lots of fruits, vegetables, whole grains and legumes
  • Limit the consumption of meat. Prefer lean meat over processed and red meat
  • Reduce the intake of salt and sugar
  • Avoid consumption of alcohol

Reference:

  1. Abigail Sido, Sridhar Radhakrishnan, Sung Woo Kim, Elisabeth Eriksson, Frank Shen, Qunhua Li, Vadiraja Bhat, Lavanya Reddivari, Jairam K.P. Vanamala. A food-based approach that targets interleukin-6, a key regulator of chronic intestinal inflammation and colon carcinogenesis. The Journal of Nutritional Biochemistry, (2017); 43: 11  DOI: 10.1016/j.jnutbio.2017.01.012

Source: Medindia

Citations   close

Please use one of the following formats to cite this article in your essay, paper or report:

  • APA

    Shirley Johanna. (2017, September 22). Whole Foods Lower Risk of Colon Cancer. Medindia. Retrieved on May 22, 2022 from https://www.medindia.net/news/healthinfocus/whole-foods-lower-risk-of-colon-cancer-173231-1.htm.

  • MLA

    Shirley Johanna. "Whole Foods Lower Risk of Colon Cancer". Medindia. May 22, 2022. <https://www.medindia.net/news/healthinfocus/whole-foods-lower-risk-of-colon-cancer-173231-1.htm>.

  • Chicago

    Shirley Johanna. "Whole Foods Lower Risk of Colon Cancer". Medindia. https://www.medindia.net/news/healthinfocus/whole-foods-lower-risk-of-colon-cancer-173231-1.htm. (accessed May 22, 2022).

  • Harvard

    Shirley Johanna. 2021. Whole Foods Lower Risk of Colon Cancer. Medindia, viewed May 22, 2022, https://www.medindia.net/news/healthinfocus/whole-foods-lower-risk-of-colon-cancer-173231-1.htm.

Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
What's New on Medindia
Prevent Hacking of Medical Devices: FDA Sounds Alarm
Black Water: Benefits and Uses
World Hypertension Day 2022 - Measure Blood Pressure Accurately, Control It, Live Longer!
View all
Recommended Reading
News Archive
Date
Category
Advertisement
News Category

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Cancer and Homeopathy Colo-rectal cancer - Management Colorectal Cancer Why Do We Eat - Nutrition Facts Diet Lifestyle and Heart Disease Cancer Facts Cancer Tattoos A Body Art Colon Crohns Disease 

Most Popular on Medindia

Noscaphene (Noscapine) Daily Calorie Requirements Turmeric Powder - Health Benefits, Uses & Side Effects Sinopril (2mg) (Lacidipine) Selfie Addiction Calculator How to Reduce School Bag Weight - Simple Tips Nutam (400mg) (Piracetam) Sanatogen The Essence of Yoga Vent Forte (Theophylline)

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2022

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use