- A study by a research team from Paris Translational Research Centre has found that pre-existing antibodies indicate a better outcome of kidney transplant.
- Patients with pre-existing antibodies were earlier not recommended for a kidney transplant, but, this study throws light on the benefits of having pre-existing antibodies.
- The study identifies the need for therapeutic targets to preserve kidneys by monitoring de novo antibody synthesis post kidney transplant.
The antibodies produced in transplant recipients before donor kidney transplant were found to be associated with better outcomes than if the antibodies were produced after the transplant, according to a study published in the Journal of the American Society of Nephrology (JASN).
Antibody response produced against donor organs are the main reason for rejection and they can be produced
- Before the transplantation (donor specific antibodies)
- After the transplantation (de novo specific antibodies)
- 103 patients had antibodies that were present before transplantation that were donor-specific
- 102 patients developed antibodies after transplantation- de novo
- 63% in patients with pre-existing antibodies
- 34% in patients with de novo antibodies
Living Kidney Transplantation Program in India
- There have been great strides in the living kidney transplantation program in India over the past 45 years, making it largest program in the world in terms of mere number of transplants done every year. The Indian parliament passed the law associated with transplantation in 1995 which has made transplantation from brain death's also possible. Chronic kidney disease leads to approximately 735,000 deaths annually.
- Between 151 and 232 per million population require kidney transplantation in India due to end stage kidney disease.
- Only 7500 kidney transplantations are currently provided in about 250 kidney transplant centers in India.
- Out of them only 10% were from deceased donors while 90% were from living donors.
Current strides in medical treatment have allowed the use of immune suppressive drugs as opposed to the use of steroids that were given earlier to prevent graft rejection. There have been many minimally invasive methods that have been devised to manage the complications associated with transplant surgery.
The current study that identifies the presence of antibodies to be a key factor in determining kidney rejection would aid in providing better care for kidney transplant patients. There is a need to closely monitor patients to ensure that there is no de novo increase in antibodies; suitable therapies can then be devised to ensure that the newly synthesized anti-bodies don't lead to the rejection of the kidney.
The current understanding of the importance of antibodies in kidney transplantation rejection will aid in including patients who were earlier rejected due to the presence of pre-existing antibodies. In fact, these patients were found to be better candidates than people who developed the antibodies after transplantation.
- Current trends in kidney transplantation in India - (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4970385/)
Please use one of the following formats to cite this article in your essay, paper or report:
Amrita Surendranath. (2017, March 10). Time of Antibody Response Key to Rejection in Kidney Transplant. Medindia. Retrieved on Aug 18, 2022 from https://www.medindia.net/news/healthinfocus/time-of-antibody-response-key-to-rejection-in-kidney-transplant-168485-1.htm.
Amrita Surendranath. "Time of Antibody Response Key to Rejection in Kidney Transplant". Medindia. Aug 18, 2022. <https://www.medindia.net/news/healthinfocus/time-of-antibody-response-key-to-rejection-in-kidney-transplant-168485-1.htm>.
Amrita Surendranath. "Time of Antibody Response Key to Rejection in Kidney Transplant". Medindia. https://www.medindia.net/news/healthinfocus/time-of-antibody-response-key-to-rejection-in-kidney-transplant-168485-1.htm. (accessed Aug 18, 2022).
Amrita Surendranath. 2021. Time of Antibody Response Key to Rejection in Kidney Transplant. Medindia, viewed Aug 18, 2022, https://www.medindia.net/news/healthinfocus/time-of-antibody-response-key-to-rejection-in-kidney-transplant-168485-1.htm.