About Careers Internship MedBlog Contact us
Supplementation of Vitamin B3 Prevents Glaucoma

Supplementation of Vitamin B3 Prevents Glaucoma

Font : A-A+

  • Glaucoma is one of the common neurodegenerative disease, affecting 80 percent of the people worldwide.
  • Supplementation of Vitamin B3 can offer protection against glaucoma, finds a new study.
  • The findings offer promise for developing an inexpensive and safe treatment for glaucoma.

Vitamin B3 can be effective to treat glaucoma, finds a study conducted by a research team led by Jackson Laboratory Professor and Howard Hughes, Medical Investigator Simon W.M. John.

The study was conducted in mice predisposed to glaucoma. Adding vitamin B3 to drinking water was found to be effective in preventing glaucoma.


In the study published in the journal Science, the authors noted that vitamin B3 administration eliminated the majority of age-related molecular changes, providing significant protection against glaucoma. This finding shows promise for developing an inexpensive and safe treatments for glaucoma.


Glaucoma is a neurodegenerative condition, affecting 80 million people worldwide. In most patients with glaucoma, intraocular pressure or high pressure inside the eye causes dysfunction and loss of retinal ganglion cells (neuronal cells that connect the eye to the brain via the optic nerve).

Age is a major risk factor for glaucoma, which contributes to harmful elevation of intraocular pressure and increased neuronal vulnerability to pressure-induced damage.

"We wanted to identify key age-related susceptibility factors that change with age in the eye and that therefore increase vulnerability to disease and in particular neuronal disease," said John.

Understanding of the age-related mechanism helps develop new interventions to protect people from common age-related diseases.

Effect of Vitamin B3 in Preventing Glaucoma

The research team conducted a variety of genomic, metabolic, neurobiological and other tests in mice susceptible to inherited glaucoma. The team discovered that NAD (Nicotinamide adenine dinucleotide), a molecule vital to energy metabolism in neurons and other cells declined with age. The decline in NAD levels reduces the reliability of neurons energy metabolism.

"There's an analogy with an old motorbike. It runs just fine, but little things get less reliable with age. One day you stress it: you drive it up a steep hill or you go on a really long journey and you get in trouble. It's less reliable than a new bike and it's going to fail with a higher frequency than that new bike," said John.

"Like taking that big hill on your old bike, some things are going to fail more often. The amount of failure will increase over time, resulting in more damage and disease progression."

Administration of Vitamin B3 (nicotinamide, an amide form of vitamin B3, also called niacinamide) increased the metabolic reliability of aging retinal ganglion cells.

"Because these cells are still healthy, and still metabolically robust even when high intraocular pressure turns on, they better resist damaging processes," said JAX Postdoctoral Associate Pete Williams, first author of the study.

Gene Therapy for Glaucoma

The research team also found that a single gene therapy application of Nmnat1 (the gene for an enzyme that makes NAD from nicotinamide) prevented glaucoma in a mouse model.

"It can be a problem for patients, especially the elderly, to take their drugs every day and in the correct dose. So gene therapy could be a one-shot, protective treatment," said Williams.

"Gene therapies through injections into the eye have been approved for rare human genetic eye disorders. Their demonstration of an important age-dependent factor may enable gene therapy for more common eye disease." The research team is pursuing clinical partnerships to test the effectiveness of Vitamin B3 in treating glaucoma patients.

Facts About Glaucoma

  • About 10% of the patients with glaucoma who receive treatment still experience loss of vision
  • Around 3 million Americans suffer from glaucoma
  • About 4.5 million people are blind due to glaucoma
  • Currently, there is no cure for glaucoma
  • Older people are at higher risk for glaucoma
  • One out of every 10,000 babies in the United States is born with glaucoma
  1. Williams PA, Harder JM, Foxworth NE, et al. Vitamin B3 modulates mitochondrial vulnerability and prevents glaucoma in aged mice. Science (2017), DOI: 10.1126/science.355.6326.706-g
  2. Glaucoma - Definition - (http://www.mayoclinic.org/diseases-conditions/glaucoma/basics/definition/con-20024042)
  3. Facts About Glaucoma - (https://nei.nih.gov/health/glaucoma/glaucoma_facts)
Source: Medindia

Citations   close

Please use one of the following formats to cite this article in your essay, paper or report:

  • APA

    Shirley Johanna. (2017, February 17). Supplementation of Vitamin B3 Prevents Glaucoma. Medindia. Retrieved on Sep 25, 2022 from https://www.medindia.net/news/healthinfocus/supplementation-of-vitamin-b3-prevents-glaucoma-167898-1.htm.

  • MLA

    Shirley Johanna. "Supplementation of Vitamin B3 Prevents Glaucoma". Medindia. Sep 25, 2022. <https://www.medindia.net/news/healthinfocus/supplementation-of-vitamin-b3-prevents-glaucoma-167898-1.htm>.

  • Chicago

    Shirley Johanna. "Supplementation of Vitamin B3 Prevents Glaucoma". Medindia. https://www.medindia.net/news/healthinfocus/supplementation-of-vitamin-b3-prevents-glaucoma-167898-1.htm. (accessed Sep 25, 2022).

  • Harvard

    Shirley Johanna. 2021. Supplementation of Vitamin B3 Prevents Glaucoma. Medindia, viewed Sep 25, 2022, https://www.medindia.net/news/healthinfocus/supplementation-of-vitamin-b3-prevents-glaucoma-167898-1.htm.


News A-Z
What's New on Medindia
Test Your Knowledge About Chromosomes?
Eating During Sunlight Hours Minimizes Mood Vulnerabilities
Know More About the Digestive System
View all
Recommended Reading
News Archive
News Category

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Calcium and Vitamin Supplements Glaucoma Vitamin Supplements Vitamin C / Ascorbic acid Vitamin B6 Vitamin B9 Vitamin B-12 Vitamin-F Eye Vision 

Most Popular on Medindia

Loram (2 mg) (Lorazepam) Sanatogen A-Z Drug Brands in India Drug Side Effects Calculator Selfie Addiction Calculator Calculate Ideal Weight for Infants Nutam (400mg) (Piracetam) Blood - Sugar Chart Vent Forte (Theophylline) Find a Doctor
This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use

Supplementation of Vitamin B3 Prevents Glaucoma Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests