- In this research, scientists Xu et al., from Germany explore a new hybrid sperm micromotor which has the potential to deliver targeted drugs in gynecological cancers
- The researchers loaded the motile sperm with an anticancer drug (doxorubicin hydrochloride) and guided it to a tumor cell where the drug was delivered via sperm-cancer cell membrane fusion
- The researchers found that sperms have the natural ability to load and deliver drugs and do not express disease-causing proteins, qualities that make them excellent vehicles for delivering anti-cancer drugs especially in the female reproductive system.
The challenge in treating cancers is the lack of an effective drug-delivery system providing local dosing in controlled amounts. Targeted drug delivery is important to minimize the side effects of cancer treatments. Research has experimented with various carrier vehicles like stem cells and bacteria to act as drug delivery systems. The challenge was for the drug to reach the actual organ without getting diluted by other body fluids. When bacteria were used as carriers, the body's immune system tracked the bacteria down and destroyed them. Scientists Xu et al., from Germany were looking for a viable, self-propelled cell as a safe alternative to carrying drugs into cancer cells.
In this research, the authors explore a novel bio-carrier which has the potential to deliver targeted drugs in gynecological cancers including cervical, ovarian, vaginal, uterine, vulvar and fallopian tube cancers. Sperms are naturally suited for swimming in the female reproductive tract and presented a viable option. The researchers reported a new hybrid sperm micromotor which consists of a motile sperm for propulsion and used as a drug carrier, and a 3D printed four-armed microtube known as a tetrapod used for guiding and delivering the drug. The researchers loaded motile bovine sperm with an anticancer drug (doxorubicin hydrochloride - DOX-HCl) and guided it to tumor spheroids. They first used it on HeLa cells and then on HeLa spheroids. When the biohybrid micromotor hit the tumor wall, the sperm was freed enabling it to swim into the tumor and deliver the drug via sperm-cancer cell membrane fusion. The researchers found that DOX-HCl was evenly distributed in the HeLa cell clusters indicating high tumor-cell killing efficiency within the first 48 hours.
Unlike other microorganisms, sperms do not express disease-causing proteins or form other undesirable colonies. The researchers found that sperms were able to navigate complex environments. Sperms can also remain functional in the body as opposed to other foreign agents because of their ability to inhibit immune response. The qualities of the sperm make it an excellent vehicle for delivering anti-cancer drugs or any other drug especially in diseases of the female reproductive system. The researchers believe sperm-hybrid systems have immense potential for application in situ cancer diagnosis and treatments.
- Haifeng Xu, et al., "Sperm-Hybrid Micromotor for Targeted Drug Delivery," ACS Nano, (2017); DOI: 10.1021/acsnano.7b06398
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Dr. Namitha Kumar. (2017, December 22). Sperm-driven Systems for Targeted Drug Delivery in Cancer. Medindia. Retrieved on Aug 18, 2022 from https://www.medindia.net/news/healthinfocus/sperm-driven-systems-for-targeted-drug-delivery-in-cancer-175707-1.htm.
Dr. Namitha Kumar. "Sperm-driven Systems for Targeted Drug Delivery in Cancer". Medindia. Aug 18, 2022. <https://www.medindia.net/news/healthinfocus/sperm-driven-systems-for-targeted-drug-delivery-in-cancer-175707-1.htm>.
Dr. Namitha Kumar. "Sperm-driven Systems for Targeted Drug Delivery in Cancer". Medindia. https://www.medindia.net/news/healthinfocus/sperm-driven-systems-for-targeted-drug-delivery-in-cancer-175707-1.htm. (accessed Aug 18, 2022).
Dr. Namitha Kumar. 2021. Sperm-driven Systems for Targeted Drug Delivery in Cancer. Medindia, viewed Aug 18, 2022, https://www.medindia.net/news/healthinfocus/sperm-driven-systems-for-targeted-drug-delivery-in-cancer-175707-1.htm.