About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
 Scientists Uncover Mechanism of Healing an Injured Heart
Advertisement

Scientists Uncover Mechanism of Healing an Injured Heart

Font : A-A+

Highlights:
  • A mechanism of healing the heart muscle following injury discoverd
  • Paves the way to develop newer and effective treatments for heart failure
  • Inactivation of a cellular pathway in heart muscle cells promotes healing and repair of the heart muscle
  • Treatments for heart failure must, specifically target the Hippo pathway in heart muscle cells without targeting fibroblasts, so that heart failure treatment is effective

Novel mechanism has been discovered that helps in healing the injured heart muscle. Inactivation of the Hippo cellular pathway in adult heart muscle promotes regeneration after injury. This finding is opening up avenues for research into developing promising heart failure treatments.

The study was undertaken by a team of scientists at Baylor College of Medicine, the Texas Heart Institute and the University of Texas Health Science Center at Houston. The findings of the study appear in the journal Genes & Development.

Advertisement

Scientists Uncover Mechanism of Healing an Injured Heart

Dr. James Martin, corresponding author of the study, director of the Cardiomyocyte Renewal Lab at the Texas Heart Institute and professor and Vivian L. Smith Chair in Regenerative Medicine at Baylor College, said: "Heart failure remains the leading cause of mortality in the U.S., and one of the interests of my lab is to develop ways to heal heart muscle by studying cellular pathways involved in heart development and regeneration."

Inactivation of Hippo Cellular Pathway on Heart Function

  • During previous research, the study team discovered that inactivating the Hippo cellular pathway in adult murine hearts promoted heart muscle repair and regeneration following a heart attack
  • These findings were promising and paved the way to develop heart failure treatments targeting the Hippo pathway
  • In the current study, the study team once again investigated the role of the Hippo pathway in the adult murine heart, focusing this time on heart fibroblasts, which are non-muscle cells found in close association with heart muscle cells (myocytes)
  • During the study, the team conducted several experiments, including single-cell sequencing experiments which provided a high degree of resolution to their tests
  • The studies showed that inactivating the Hippo pathway in normal resting adult hearts without stimulated activation and proliferation of fibroblasts with the formation of scar tissue or fibrosis within the heart muscle
  • Mouse hearts with defective Hippo cellular pathway in heart fibroblasts spontaneously developed fibrosis and scarring of heart muscle resulting in severe heart failure
The findings of the study suggest that inactivating the Hippo cellular pathway in heart fibroblasts can cause or aggravate pre-existing failure. Therefore, heart failure treatments must, specifically target inactivation of the Hippo pathway in cardiac muscle cells.
  • Additionally, the team found that inactivating the Hippo pathway resulted in a cascade of events in the cell a leading to an inflammatory response mediated by Yap, a molecule which controls several cellular pathways
"We know that Hippo and Yap work together. Hippo acts like a brake for Yap, so when we took away Hippo, Yap remained active and regulated the expression of important signaling molecules that 'talk' to macrophages and other immune cells luring them into the heart," Martin said.

Heart Failure in Brief

  • During a heart attack, the blood supply to the heart muscle is affected and therefore, they are deprived of oxygen
  • As a result, the affected portion of the heart muscle undergoes infarction or dies
  • The damaged heart muscle does not regenerate and instead becomes replaced with scar tissue or fibrosis, due to stimulation of heart fibroblasts
  • When there is excessive scarring, the heart progressively weakens and is unable to contract and pump blood
  • As a result, following a heart attack, persons can develop heart failure which is a potentially fatal condition

Scope of the Study

  • The study identifies key cellular pathways involved in heart muscle regeneration following injury and opens up future avenues of research into developing heart failure treatments
  • Importantly, fibroblasts in the heart must be maintained in the inactive or resting state since activation can result in worsening of heart failure
In summary, scientists discovered a key cellular pathway, the Hippo pathway in the heart muscle, which can be specifically targeted to develop heart failure treatments in the future.

Source: Medindia
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Advertisement
News Category
What's New on Medindia
International Day of Persons with Disabilities 2021 - Fighting for Rights in the Post-COVID Era
Effect of Blood Group Type on COVID-19 Risk and Severity
Woman with Rare Spinal Cord Defect from Birth Sues Doctor
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Heart Benefits of Meditation / Meditation Therapy Healthy Heart Anal Warts Statins Mitral Valve Prolapse Aortic Valve Stenosis Pericarditis 

Recommended Reading
New Dual Stem Cell Therapy Holds Promise for Heart Regeneration
Newly developed dual stem cell therapy offers fresh hope for repairing myocardial infarction (MI) .....
Can Scar Tissue After a Heart Attack be Turned Back into Functioning Heart Muscle?
Can scar tissue after a heart attack be turned back into functioning heart muscle using stem cells ....
Calculate Your Lifetime Risk of Heart Attack
Heart Risk Calculator assesses the lifetime risk for a heart attack and helps in making the right .....
Vitamin E can Prevent Muscle Damage After Heart Attack
Vitamin E is an effective, low-cost therapy for preventing muscle damage in heart attack patients. ....
Anal Warts
Anal warts or genital warts are soft bumps caused by Human Papilloma Virus and are a sexually transm...
Aortic Valve Stenosis
Aortic valve Stenosis is an abnormal narrowing of the c valve. Symptoms include angina, and that of ...
Benefits of Meditation / Meditation Therapy
Meditation therapy is one of the best Alternative Therapies. It is a Mind-Body Medicine....
Mitral Valve Prolapse
Mitral Valve Prolapse is a relatively common condition and causes leakage of blood through the valve...
Pericarditis
Pericarditis occurs when the pericardium gets inflamed. Pericarditis is characterized by severe ches...
Statins
Statins are new wonder drugs that are proving to be efficacious, not merely in relieving symptoms bu...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use