- Miscarriage is a
pregnancy loss in women that occurs during the
- Progesterone hormone offers new hope to
prevent recurrent miscarriage in women.
- Women with
recurrent pregnancy loss can be benefited by the safe and inexpensive treatment
offers hope for a successful birth in women who suffer from multiple pregnancy
losses in the first four or six weeks of gestation, finds a new study from the
Yale School of Medicine and their research team at University of Illinois at
The study findings were
published in the issue of Fertility and Sterility,
the Journal of the
American Society for Reproductive Medicine.
‘Miscarriage can be prevented by a beneficial, safe and inexpensive treatment option using progesterone.’
Fetal death affects
30000 women every year in the United States. Around 25% of women who become
pregnant have a first-trimester loss.
Progesterone is a
steroid hormone produced by the corpus luteum (temporary endocrine gland). It
helps the endometrium to prepare for pregnancy after ovulation.
The research team
studied the effects of micronized plant-derived progesterone hormone in 116
women who had multiple pregnancy losses.
function test (EFT)
was created by Harvey J Kliman, M.D., director of the
Reproductive and Placental Research Unit in the Department of Obstetrics,
Gynecology and Reproductive Sciences at Yale School of Medicine and was used to
determine whether the endometrium is healthy and can sustain the embryo.
An abnormal endometrial
function test was found to be associated with pregnancy failure while a normal
endometrial function test may result in pregnancy success.
The research team also
focused on nCycline biomarker
which can assess recurrent pregnancy loss
Women who had abnormal
nCycline levels were prescribed progesterone hormone for two days after
ovulation ( time during which the uterine lining matures for pregnancy).
The scientists believed
that progesterone hormone could cause the endometrium to produce more
Kliman, said, "The
endometrium feeds the baby until the eighth week of pregnancy. Then at 9 to 10
weeks the mother's blood takes over to feed the embryo."
"In this subset of
women experiencing multiple early miscarriages, we assume that their embryos
were literally starving to death".
"They attached, but
they were not getting enough food. When we give progesterone back to these
women, the endometrium makes more nutrients and prevents their pregnancy loss,"
The researcher also
said, that the endometrial function test with the nCycline biomarker was
created initially to identify women with infertility. This study finds that the
test could also help to identify patients with multiple pregnancy loss.
Kliman worked along with
Mary Stephenson, M.D., and Dr. Theresa S. Falcon-Cullinan Professor of
Obstetrics and Gynecology at the University of Illinois at Chicago,director of
the University of Illinois Recurrent Pregnancy Loss Program.
"We are very pleased to find that these results reinforce the evidence
that progesterone could be a very beneficial, inexpensive, and safe
treatment for many women with a history of recurrent pregnancy loss."
results show us that next we need to study progesterone as a treatment for
recurrent pregnancy loss with a prospective randomized trial to validate the
- Miscarriage refers to a
pregnancy loss in women that occurs before 20 weeks of gestation.
to the American College of Obstetricians and Gynecologists (ACOG), miscarriage
is one of the common types of pregnancy loss.
problems, maternal age, lifestyle problems like smoking, drug use, malnutrition
can all be a cause for a miscarriage.
- There is a 20-35%
chance of miscarriage in women who are between the age of 35-45 years. And a
50% chance of miscarriage in women above the age of
- Eating healthy, exercising regularly and managing stress may
help to prevent miscarriage.
- Mary D. Stephenson et.al., Luteal start vaginal
micronized progesterone improves pregnancy success in women with recurrent
pregnancy loss, Fertility and Sterility; (2017) DOI link: http://dx.doi.org/10.1016/j.fertnstert.2016.11.029
- What Does Progesterone Do? - (http://www.hormone.org/hormones-and-health/what-do-hormones-do/progesterone)
- Miscarriage - (http://americanpregnancy.org/pregnancy-complications/miscarriage/)