About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Phylogica Peptide Fusion Kills Aggressive Breast Cancer Cells

Font : A-A+

Phylogica Peptide Fusion Kills Aggressive Breast Cancer Cells

Phylogica is one of the leading peptide drug discovery companies, whose libraries contain billions of unique peptides known as Phylomer peptides; they represent a rich source of biologically active drug leads. These peptides are known to have exceptional structural stability, specificity and affinity, thereby giving them the potential to address disease targets.

In a pilot study, it was proven that certain peptides which are associated with the Omomyc drug, kills drug-resistant and aggressive breast cancer cells. The principal scientist is Dr. Pilar Blancafort, one of Australia's leading breast cancer experts, associate professor at The University of Western Australia, and a member of the Harry Perkins Institute of Medical Research. She commented that the results of the study show that the company's Cell-Penetrating Peptide (CPP) fusion improves efficacy of existing anticancer drugs.

Advertisement

Dr. Blancafort said that the study also revealed that Phylogica's CPP fusion improved the efficacy of existing anticancer drugs to a great extent, including the antibody, Cetuximab and the chemotherapy agent, Docetaxel. She further stated that a combination of Cetuximab and a Phylomer CPP-Omomyc fusion was more than three times more effective at killing drug-resistant breast cancer cells as compared to any of these agents alone.

 "The ability to combine drugs to treat breast cancer is particularly exciting as it has the potential to lower the likelihood of resistance, improve drug activity and reduce chemotherapy side-effects," she explained.
Advertisement

Dr. Blancafort also tested the activity of Phylogica's CPP fusion in an in-vivo breast cancer model and found that there was a substantial reduction in tumor size. However, she was of the opinion that this pilot study needs to be repeated using larger groups to confirm its significance.

Dr. Paul Watt, the Chief Scientific Officer of Phylogica, said, "We were not expecting such a striking result from the pilot study. We believe this is the first time anyone has shown a CPP-Omomyc fusion protein to be active in vivo, as to our knowledge Omomyc has only previously been successfully delivered to tumors using a complex 'gene therapy' approach, associated with significant regulatory hurdles to clinical application."

Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Advertisement
News Category
What's New on Medindia
Fermented Skin Care
Television Binge-Watching May Boost the Risk of Deadly Blood Clots
Western Diet may Augment the Risk of Autoimmune Diseases
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Women and Cancer Breast Biopsy Pagets disease of the breast Mastitis Cancer and Homeopathy Parkinsons Disease Surgical Treatment Colorectal Cancer Breast Cancer Facts Cancer Facts Cancer 

Recommended Reading
New Therapies Researched to Treat Osteosarcoma and Ewing's Sarcoma
Lombardi Comprehensive Cancer Center researchers are involved in developing new therapies for ......
Peptide Shows Extraordinary Promise for Treating Spinal Cord Injury
Scientists at Case Western Reserve University School of Medicine have developed a new chemical ......
ANG4043, a Brain-penetrant Peptide-monoclonal Antibody Conjugate, Effective in Treating HER2-positive Intracranial Tumors
Study has revealed that ANG4043, a peptide-monoclonal antibody (mAb) conjugate, entered the brain .....
New Medication With a Peptide and Hormone can Treat Obesity and Binge Eating Disorders
Scientists have identified a peptide and a hormone produced by neurons, in a specific area of the .....
Breast Biopsy
Breast biopsy involves removing a sample of breast tissue to determine whether it is cancerous or .....
Colorectal Cancer
Colorectal cancer is a cancer that starts in the colon or the rectum. Colorectal cancer is the third...
Mastitis
Mastitis is a common cause of tenderness, swelling and pain in breast, owing to inflammation in the ...
Pagets disease of the breast
A detailed description of the Paget's disease of the breast, characteristic signs and symptoms, dete...
Women and Cancer
Cancer is one of the frequently talked about and most feared disease that falls under the genre of l...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2022

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use
open close
CONSULT A DOCTOR
I have read and I do accept terms of use - Telemedicine

Advantage Medindia: FREE subscription for 'Personalised Health & Wellness website with consultation' (Value Rs.300/-)