plaque is a sticky coating of bacteria on the teeth and gums.
the mouth, plaque is responsible for cavity formation and gum diseases.
plaque is also associated with systemic inflammation.
dental health may cause heart attacks and strokes.
plaque formation will also decrease systemic inflammation.
Plaque reducing novel
toothpaste shown to significantly decrease systemic inflammation, according to
a recent trial conducted by the Florida Atlantic University.
of the Trial
In this trial, all
subjects randomly chosen, were told to follow the same brushing protocol, and
were given a 60-day supply of either Plaque HD® toothpaste, that could identify
plaque, or a similar non-plaque identifying placebo toothpaste.
‘Maintaining good oral health and hygiene may reduce incidence of heart attacks and strokes.’
To diagnose dental plaque, all the
participants employed a fluorescein mouthwash, and intraoral images were taken
under black light
imaging. To assess systemic
inflammation, hs-CRP (high-sensitivity C- reactive protein), levels were
by an independent lab employing an enzyme linked immunosorbent
of the Trial
The study revealed
that using Plaque HD® significantly reduced dental plaque formation as well as systemic
"While the findings on reducing dental
plaque extend a previous observation, the findings on decreasing inflammation
are new and novel," said Charles H. Hennekens, M.D., senior author and Sir
Richard Doll Professor, senior academic advisor to the dean in the Charles E.
Schmidt College of Medicine at Florida Atlantic University.
Plaque HD® Reduces Plaque
Plaque HD® is the first toothpaste that shows up plaque so that it can be easily
removed by targeted brushing
. Additionally, the product's proprietary
formulation is composed of a unique blend and concentration of cleaning agents
that loosen the core of the plaque structure, making it easier for the person
to visualize and more effectively get rid of the plaque.
Protein (CRP) and Its Role in Systemic Inflammation
CRP is an acute phase protein
synthesized in the liver
. Levels of CRP increase in plasma during infection and inflammatory states and is considered one of the golden markers of inflammation
CRP is formed in response to a wide variety of inflammatory stimuli, such as
heat, trauma, hypoxia and infection.
Functions of CRP in
- CRP activates complement which plays an
important role in the immune response.
- It also promotes phagocytosis of various
- It promotes the generation of pro-inflammatory
cytokines that increase the immune response to various stimuli.
- In addition, it has a procoagulant (promotion
of clotting) effect, and plays a role in formation of atherosclerotic
lesions, which may lead to heart attacks.
CRP, is thus believed to act as a surveillance
molecule for altered self antigens as well as certain pathogens. It provides
early defense and causes a proinflammatory signal and stimulation of the
humoral, adaptive immune response.
Between CRP, Periodontal Disease and Heart Disease
Periodontal (teeth and related structures)
diseases are linked to an increase in the levels of CRP.
This is clinically important since raised CRP is now a widely accepted
measure of the level of systemic inflammation. Rise in CRP levels have also been shown to increase the risk of
atherosclerosis and heart disease
. In patients who had both atherosclerosis
and periodontal disease, levels of CRP were increased to more than the level
observed with either periodontal disease or atherosclerosis
Based on the findings of the study, Hennekens
and his team are in the process of drafting an investigator initiated research
grant proposal to the National Institutes of Health (NIH) under the stewardship
of co-author Patrick E. McBride, M.D., M.P.H., professor of medicine and
interim associate dean for faculty affairs at the University of Wisconsin
School of Medicine and Public Health.
This large scale randomized study plans to
test if Plaque HD® can reduce the risk of heart attacks and strokes. The trial
will be undertaken in the Wisconsin Network for Health Research (WiNHR) and the
Wisconsin Research and Education Network (WREN), Dr McBride being a director in
both these organizations.
Tips To Prevent Plaque Formation
The following tips may help to reduce plaque formation and promote good oral hygiene
- Brushing teeth at least twice daily
between teeth and under the gumline to remove plaque that may not be
reached by the brush.
- Reduce intake of sugary foods, especially
- Periodic visits to the dentist for cleaning
and dental check-ups
- INFLAMMATION The Relationship Between Oral Health and Systemic Disease - (https://www.adha.org/resources-docs/7823_Inflammation.pdf)
- A review of C-reactive protein: A diagnostic indicator in periodontal medicine - (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3467901/)
- Function of C-reactive protein. - (https://www.ncbi.nlm.nih.gov/pubmed/10852144)