- Chronic kidney disease
is a progressive loss of the kidney function
sodium restriction reduces albuminuria (albumin in urine) in patients with
chronic kidney disease
- The combination of a drug called
paricalcitol and a low sodium diet resulted in the lowest albuminuria levels in
Low intake of
salt may improve kidney and heart health in patients with chronic kidney disease
(CKD), claims a new study. CKD, also known as the chronic renal
disease, is a slow progressive loss of kidney function. The hallmark symptoms
of CKD are urinary excretion of proteins (proteinuria) and albumin
(albuminuria). Therapies that reduce albuminuria can have beneficial effects on
the heart, blood vessels and slow the decline in kidney function. However, currently available treatments do not eliminate albuminuria in
most of the patients, and are likely to have residual albuminuria.
Reduces Residual Albuminuria
A team of
researchers from The University Medical Center Groningen, in Netherlands,
studied two interventions that have demonstrated the potential for reducing
residual albuminuria. The two interventions are dietary sodium restriction and
a drug called paricalcitol that activates the vitamin D receptor.
‘A combination of a low-sodium diet and the drug paricalcitol can eliminate albuminuria in patients with chronic kidney disease.’
team led by Martin de Borst, MD, PhD, conducted a randomized trial involving 45
patients with CKD. Each intervention was added to the conventional treatment
regimen for a period of eight weeks.
At the end of
the clinical trial, the researchers found that dietary sodium
significantly reduced residual albuminuria and blood pressure. However, the
drug paricalcitol had no significant effect on these measures. The researchers
noted that the combination of a low-sodium diet and paricalcitol resulted in
the lowest albuminuria levels.
"What we found
was that sodium restriction provided a relatively large beneficial effect,
whereas the effect of paricalcitol was small. Thus, the impact of the combined
intervention was largely due to the protective effect of sodium restriction,"
said Dr. de Borst.
According to the
World Health Association, an average person can consume
2 grams of sodium per day. But, most of the
people consume twice as much as the recommended intake.
"In our study,
patients consumed on average 4 grams of sodium per day, which is well in line
with global trends in sodium consumption among CKD patients," said Dr. de
following our intervention aimed at reduced sodium intake, patients consumed
2.5 grams per day, which is still above the recommended level. This moderate
restriction resulted in a sharp reduction in albuminuria and blood pressure,
indicating that even a moderate reduction in sodium intake may provide serious
entitled, "The effect of vitamin D receptor activation and dietary sodium
restriction on residual albuminuria in chronic kidney disease: the ViRTUE-CKD
randomized controlled trial," appear in an upcoming issue of the
Journal of the American Society of Nephrology (JASN).
Kidney Disease Statistics
- About 10 % of the world's
population have CKD, which claims millions of lives every year due to poor
access to treatment.
- One in 3 Americans is at higher risk
of developing kidney disease. About 26 million Americans suffer from some form
of kidney disease.
- China and India are estimated to have
the highest number of kidney failure patients.
- The two
major causes of CKD are high blood pressure and type 2 diabetes.
- Men with kidney disease are more likely to progress to
- A protein that defines the melanoma
blueprint - (https://www.eurekalert.org/pub_releases/2016-11/cndi-apt111616.php)
- Kidneys - (https://www.kidney.org/news/newsroom/factsheets/FastFacts)
- Global Facts: About Kidney Disease -