About Careers Internship MedBlog Contact us
How to Prevent Urinary Tract Infection Recurrence Without Antibiotics

How to Prevent Urinary Tract Infection Recurrence Without Antibiotics

Font : A-A+

  • Urinary tract infection caused by E. coli is normally treated with antibiotics
  • Repeated antibiotic use for recurrent infection could lead to antibiotic resistance
  • A new approach using mannosides could circumvent the need for antibiotics for E. coli urinary tract infection and reduce the recurrence of infections

A fresh approach using mannosides for the treatment of urinary tract infection caused by E.coli has the potential to prevent recurrence of the infection without the repeated need for antibiotics. A study indicating the same was published in Nature.

Escherichia coli (E. coli) are common bacteria that spread through contaminated food and water. Many E coli residing in the digestive tract do not cause digestive problems but can spread from the anal region to the lower urinary tract resulting in symptoms of frequent urination, urgency to pass urine, and a burning sensation while passing urine. Urinary tract infections are more common and tend to be recurrent in women, due to the smaller length of the urethra in females. Recurrent and untreated infection can spread to and damage the kidneys, or increase the risk of premature deliveries in pregnant women.


Urinary tract infections are treated with urinary antiseptics and antibiotics. In the recent years, stress has been placed on the importance of using antibiotics only when needed, to prevent the development of resistance. Antibiotic resistance refers to the ineffectiveness of antibiotics due to incorrect use, for example, not completing the course of treatment, or using an antibiotic for a viral infection.

Alternatives to antibiotics for the treatment of urinary tract infection are the need of the hour. Researchers are now evaluating the use of certain molecules called mannosides to treat urinary tract infection. Mannosides are chemically related to mannose, molecules to which the bacteria attach and remain latched to the inner lining of the urinary tract.

The E. coli have projections called pili with which they attach to mannose receptors on the bladder cells and cause infection. When mannosides are administered, the bacteria attach to these similar molecules instead, and get flushed out when the person urinates.

An approach that uses mannosides has the potential to reduce the use of antibiotics. Advantages of using such an approach include the following:
  • The lethal effect of antibiotics on normal gut bacteria is avoided. Normal gut bacteria keep harmful bacteria at bay and maintain digestive health
  • Antibiotic resistance is avoided
The researchers tested the possible effect of mannosides in preventing recurrent urinary tract infection in mice. They hypothesized that if the E. coli population within the gut is reduced, the chances of recurrence of urinary tract infection could also reduce. They introduced E. coli into the bladder and the gut of mice. This was followed by three oral doses of mannoside. The researchers found that:
  • The bacteria were almost completely eliminated from the urinary bladder
  • The bacterial count in the gut was around a hundred times lesser than before the treatment, probably because the mannosides prevented the attachment of the bacteria to the gut cells
  • The count of the normal bacteria in the gut that do not cause urinary infection was only minimally affected
Mannosides thus have a potential to not only treat a urinary tract infection but also prevent recurrence. More importantly, as a result of their mechanism of action, they could also eliminate antibiotic-resistant bacteria, without the need for stronger antibiotics, which are often associated with more side effects. Clinical trials should be able to confirm the possible benefits of this treatment in patients, especially women, with recurrent urinary tract infection.

Reference :
  1. Spaulding CM et al. Selective depletion of uropathogenic E. coli from the gut by a FimH antagonist. Nature (2017); doi:10.1038/nature22972
Source: Medindia

Citations   close

Please use one of the following formats to cite this article in your essay, paper or report:

  • APA

    Dr. Simi Paknikar. (2017, June 16). How to Prevent Urinary Tract Infection Recurrence Without Antibiotics. Medindia. Retrieved on Sep 25, 2022 from https://www.medindia.net/news/healthinfocus/how-to-prevent-urinary-tract-infection-recurrence-without-antibiotics-170924-1.htm.

  • MLA

    Dr. Simi Paknikar. "How to Prevent Urinary Tract Infection Recurrence Without Antibiotics". Medindia. Sep 25, 2022. <https://www.medindia.net/news/healthinfocus/how-to-prevent-urinary-tract-infection-recurrence-without-antibiotics-170924-1.htm>.

  • Chicago

    Dr. Simi Paknikar. "How to Prevent Urinary Tract Infection Recurrence Without Antibiotics". Medindia. https://www.medindia.net/news/healthinfocus/how-to-prevent-urinary-tract-infection-recurrence-without-antibiotics-170924-1.htm. (accessed Sep 25, 2022).

  • Harvard

    Dr. Simi Paknikar. 2021. How to Prevent Urinary Tract Infection Recurrence Without Antibiotics. Medindia, viewed Sep 25, 2022, https://www.medindia.net/news/healthinfocus/how-to-prevent-urinary-tract-infection-recurrence-without-antibiotics-170924-1.htm.


News A-Z
What's New on Medindia
Test Your Knowledge About Chromosomes?
Eating During Sunlight Hours Minimizes Mood Vulnerabilities
Know More About the Digestive System
View all
Recommended Reading
News Archive
News Category

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Cystitis Cystoscopy Urinary Tract Infection Vesico-Ureteric Reflux Causing UTI in Children Hydronephrosis / Antenatal Counseling Diet for Kidney stones Flu Stones in Urinary Tract Interstitial Cystitis MRSA - The Super Bug 

Most Popular on Medindia

Nutam (400mg) (Piracetam) Post-Nasal Drip How to Reduce School Bag Weight - Simple Tips Iron Intake Calculator Calculate Ideal Weight for Infants Pregnancy Confirmation Calculator Blood Donation - Recipients Blood - Sugar Chart Color Blindness Calculator Loram (2 mg) (Lorazepam)
This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use

How to Prevent Urinary Tract Infection Recurrence Without Antibiotics Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests