metastasizes to distant sites. These cancer cells lack three receptors targeted
by current chemotherapy regimens.
‘The plant compound called luteolin is a flavonoid that prevents the migration of triple-negative breast cancer cells throughout the body.’
breast cancer cells lack three receptors, and common cancer drugs can't 'find'
the cells, and doctors must treat cancer with extremely aggressive and highly
toxic treatment strategies," said Salman Hyder, the Zalk Endowed Professor
in Tumor Angiogenesis and professor of biomedical sciences in the College of
Veterinary Medicine and the Dalton Cardiovascular Research Center.
this type of breast cancer also frequently develop metastatic lesions that
originate from drug-resistant cells. Therefore, safer therapeutic therapies
that are more effective are being sought for this deadly type of cancer in
Luteolin - Natural
Compound Reduces Risk of Triple-Negative Breast Cancer
non-toxic plant compound called luteolin is found in herbs and vegetables
such as parsley, thyme, celery, and broccoli.
Luteolin has been proven
effective against many types of cancer.
is a flavonoid which has been used in Chinese
traditional medicine for treating various conditions including hypertension and
team tested the effect of luteolin in suppressing the metastasis in human
triple-negative breast cancer cells grown in mice. The findings showed that the
plant compound luteolin subdued the metastasis of triple-negative cancer in the
lungs of affected mice.
exposed to human triple-negative breast cancer cells experienced significantly
reduced metastatic growth in their lungs after being treated with
luteolin," said Hyder.
every case, the mice also saw no weight loss, which means luteolin has no toxic
effects; this plant compound is both safe and effective."
team also tested the effect luteolin on subduing the migration of
triple-negative breast cancer cells throughout the body. The triple-negative
breast cancer cells grown in the dishes were treated with luteolin. The
migration of the triple-negative breast cancer cells was inhibited by the plant
breast cancer cells are highly mobile in the body, which helps them metastasize
to other organs throughout the body," said Hyder. "We found that
luteolin inhibits that migration and also can kill cancer cells. We contend
that these studies support further investigation of luteolin as an
anti-metastatic agent that could be used to combat triple-negative breast
cancer and its metastasis."
Hyder and his
team said that the early-stage results are promising. If the additional studies
are successful, the research team will request the authority from the federal
government to begin human drug development, followed by human clinical trials
to develop new treatments for triple-negative breast cancer in women.
Triple-Negative Breast Cancer
- Triple-negative breast cancer
lacks three receptors that fuel most breast cancer tumors- estrogen,
progesterone, and HER2-neu
- There is no targeted treatment for
triple-negative breast cancer
- Triple-negative breast cancer
affects younger women and those with BRCA1 mutations.
- For every half an hour, one
American woman is diagnosed with triple-negative breast cancer
- It is aggressive, difficult to
treat and more likely to spread and recur
- Triple Negative Breast Cancer - (http://www.nationalbreastcancer.org/triple-negative-breast-cancer)
- Triple Negative Breast Cancer Fact Sheet - (https://tnbcfoundation.org/tnbc-facts/)
- Luteolin, a flavonoid with potentials for cancer prevention and therapy - (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2615542/)