- Nicotinamide adenine dinucleotide (NAD) - a co-enzyme found in
living cells has a role in pharmacology and use in the future treatment
for various diseases
are studying the consequences of NAD deficiency and are looking into how
effective it would be in reversing the signs of muscle and cell atrophy by
enhancing the production of NAD.
studies on mouse models indicate that NAD can reverse the signs of aging,
however it is still under contemplation until controlled clinical trial
can prove it.
otherwise know as the powerhouse or the
batteries of the cell, is a structure inside a cell, its most important
function is to produce energy, by taking nutrients from the cell, breaking it
down and turning it into energy.
As we grow older the cells in our bodies
also get damaged due to various factors, which in turn contributes to the aging
‘Helper molecule could hold the key to being young and staying young, as studies show that manipulating NAD (nicotinamide adenine dinucleotide ) could erase the signs of aging.’
NAD ( Nicotinamide Adenine Dinucleotide
), is the coenzyme form of the vitamin niacin, it functions as one of the most
important coenzyme in every cell of our body and plays an essential role in
many biochemical reactions such as energy metabolism, mitochondrial functions,
calcium homeostasis, gene expression, immunological function, aging and cell
Studies in the past have found that there
is an inverse relationship between NAD and our natural aging process
irrespective of one's personal health, diet or physical fitness.
With age NAD levels decrease
making it difficult for cells to process energy leading to impairment and
depletion of mitochondria, the most important factor in aging.
A latest study done by researcher Joseph
Baur, from Perelman School of Medicine, on mouse models studied the role of NAD
precursor molecules by targeting the NAD salvage pathway and thereby trying to
resynthesize and make fresh NAD to maintain optimal vital reactions thus
combating age-related cell damage and preventing the natural course of aging.
While studying the effect of restricting
the amount of NAD in specific tissue, to stimulate the process of normal aging
on young mice models, Baur and team found that, the mice tolerated NAD well
without losing spontaneous activity however they accidently found to their
surprise that when the mice reached adulthood they showed signs of muscle
atrophy, similar changes seen in muscular dystrophy
Next they tested the effect of dietary
form of vitamin B3 on the mice and found a drastic and almost complete reversal
of muscle atrophy symptoms. The research team also found that if there was an
induced lifelong over expression of nicotinamide phosphoribosyltransferase
(NAMPT), it maintained the exercise capacity in aged mice, thus proving that
enhancing muscle NAD synthesis could battle age-associated atrophy.
The effect of NAMPT is controversial and
is still a matter of debate and further research has to be done to confirm
Although various studies have been done
on NAD and its positive health benefits, especially its role in reversing the
aging process, more research needs to be done to study its long term effects.
Over the counter supplements of NAD first
came into the market in 2013 and it claims to reverse the signs of aging with
one supplement a day, however the supplements are under dosed and you will not
be able to see any noticeable difference. A better alternative would be the use
of Vitamin B3
, specifically the type nicotinamide riboside, as it
is said to increase NAD levels, however it would be a good idea to consult your
doctor before starting any supplements.
- Penn study illuminates role of essential compound in maintaining physical endurance, possible MD treatment - Newswise
- Actions & Reactions - (https://publications.nigms.nih.gov/chemhealth/act.htm)
- Nicotinamide phosphoribosyltransferase (Nampt): a link between NAD biology, metabolism, and diseases. - (http://www.ncbi.nlm.nih.gov/pubmed/19149599)