called epigallocatechine-3-gallate (EGCG), which is found in green tea leaves
may be beneficial for people with multiple myeloma and amyloidosis, which are
fatal medical conditions associated with bone marrow disorders.
‘A compound in green tea called epigallocatechine-3-gallate (EGCG), prevented the dangerous accumulation of misshapen antibodies in patients with bone marrow disorders.’
EGCG is a
polyphenol compound found in green tea leaves. Patients with bone marrow
disorders are susceptible to a fatal condition called light chain amyloidosis.
In this condition, the body's own
antibodies become misshapen and can accumulate in the heart and kidneys.
How EGCG Prevents Bone
Lead author of
the study, Jan Bieschke from Washington University in St. Louis, US, said, "We
wanted to understand how light chain amyloidosis works and how the green tea
compound affects this specific protein."
team isolated individual light chains amyloid from nine patients with bone
marrow disorders, which causes multiple myeloma or amyloidosis. Lab experiments
were conducted to determine how the green tea compound affected the light chain
with bone marrow disorders, the EGCG compound in green tea pulled the light
chain protein into a different type of aggregate, which was not toxic and did
not form fibril structures.
team found that the EGCG transformed light chain amyloid, preventing the
misshapen form from replicating and accumulating dangerously.
The study is
published in the Journal of Biological Chemistry.
Amyloidosis is a
rare disease in which the substance called amyloid build-up in the vital
organs. Amyloid is a protein produced in the bone marrow, which can be
accumulated in any tissue or organ, including the heart, kidneys, liver,
spleen, nervous system and digestive tract.
The severe form
of amyloidosis can be life-threatening organ failure. There is no cure for
amyloidosis. However, the symptoms and the production of the amyloid protein
can be managed.
- Amyloidosis - (http://www.mayoclinic.org/diseases-conditions/amyloidosis/basics/definition/con-20024354)