- A compound in green tea could be a life-saver for people with bone marrow disorders.
- Patients with bone marrow disorders often suffer from a fatal condition called amyloidosis (accumulation of amyloid in the organs).
- The compound called Epigallocatechine-3-gallate (EGCG) prevents misshapen accumulation of antibodies.
has been linked to boosting metabolism and aiding in weight loss. Now a new
study shows that a compound in green tea could treat bone-marrow disorders.
The compound called epigallocatechine-3-gallate (EGCG), which is found in green tea leaves may be beneficial for people with multiple myeloma and amyloidosis, which are fatal medical conditions associated with bone marrow disorders.
How EGCG Prevents Bone Marrow Disorders?
Lead author of the study, Jan Bieschke from Washington University in St. Louis, US, said, "We wanted to understand how light chain amyloidosis works and how the green tea compound affects this specific protein."
The research team isolated individual light chains amyloid from nine patients with bone marrow disorders, which causes multiple myeloma or amyloidosis. Lab experiments were conducted to determine how the green tea compound affected the light chain proteins.
In patients with bone marrow disorders, the EGCG compound in green tea pulled the light chain protein into a different type of aggregate, which was not toxic and did not form fibril structures.
The research team found that the EGCG transformed light chain amyloid, preventing the misshapen form from replicating and accumulating dangerously.
The study is published in the Journal of Biological Chemistry.
Amyloidosis is a rare disease in which the substance called amyloid build-up in the vital organs. Amyloid is a protein produced in the bone marrow, which can be accumulated in any tissue or organ, including the heart, kidneys, liver, spleen, nervous system and digestive tract.
The severe form of amyloidosis can be life-threatening organ failure. There is no cure for amyloidosis. However, the symptoms and the production of the amyloid protein can be managed.
- Amyloidosis - (http://www.mayoclinic.org/diseases-conditions/amyloidosis/basics/definition/con-20024354)
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Shirley Johanna. (2017, February 08). Green Tea may Prevent Amyloidosis in Patients With Bone Marrow Disorders. Medindia. Retrieved on Aug 18, 2022 from https://www.medindia.net/news/healthinfocus/green-tea-may-prevent-amyloidosis-in-patients-with-bone-marrow-disorders-167643-1.htm.
Shirley Johanna. "Green Tea may Prevent Amyloidosis in Patients With Bone Marrow Disorders". Medindia. Aug 18, 2022. <https://www.medindia.net/news/healthinfocus/green-tea-may-prevent-amyloidosis-in-patients-with-bone-marrow-disorders-167643-1.htm>.
Shirley Johanna. "Green Tea may Prevent Amyloidosis in Patients With Bone Marrow Disorders". Medindia. https://www.medindia.net/news/healthinfocus/green-tea-may-prevent-amyloidosis-in-patients-with-bone-marrow-disorders-167643-1.htm. (accessed Aug 18, 2022).
Shirley Johanna. 2021. Green Tea may Prevent Amyloidosis in Patients With Bone Marrow Disorders. Medindia, viewed Aug 18, 2022, https://www.medindia.net/news/healthinfocus/green-tea-may-prevent-amyloidosis-in-patients-with-bone-marrow-disorders-167643-1.htm.