a common phenomenon, but the magnitude varies for
different people. Earlier studies have shown that people whoencounter abnormal increase in
blood pressure levels during
exercise will experience
in the future.
‘Genetic mutations in receptor molecules of skeletal muscle cells influence the way the personís heart rate and blood pressure respond to exercise.’
Thus, understanding why people react differently to exercise is
to identify risk factors and conduct early monitoring or treatment for those individuals at risk.
measured the heart rate and blood
of 200 healthy young men and women before and during a handgrip exercise and analyzed their DNA
for genetic risk factors.
showed that the difference in responses might be caused by the genetic
variations in receptors found in skeletal muscles. Receptors are protein
molecules present on cell surfaces that bind to a drug or a hormone and
initiate a change within the cell.
Scientists identified two
common genetic mutations in skeletal muscle receptors that were responsible for higher blood pressure during exercise when
people who did not have them. The difference was more pronounced in men.
The limitations of the study included a small sample size and the
use of only one specific type of exercise. However, the effect of these genetic
variants in the skeletal muscle receptors was significant.
will be needed to look at other types of exercise and to replicate this
Millar, the corresponding author of the study, commented on the findings of the
results 'This research suggests the presence of these receptors can contribute
to larger blood pressure responses during exercise - a risk factor for future
problems with the heart or blood vessels. It is important to examine why we saw this difference mainly in men, and to understand the
specific mechanisms behind how these genetic variants influence their heart
rate and blood pressure responses to exercise.'
- "TRPV1 and BDKRB2 receptor polymorphisms can influence the exercise pressor reflex", Journal of Physiology (2018). physoc.onlinelibrary.wiley.com ... doi/10.1113/JP276526