has uncovered this mechanism whereby the human genome coordinates the regulation of genes in each neuron to enable the nose to detect specific scents.
Stavros Lomvardas, Ph.D., Mortimer B. Zuckerman Mind Brain Behavior Institute at Columbia University; the principal investigator of the study said that the mechanism where a finite number of genes work towards distinguishing an infinite number of nuanced scents has been detected. Olfaction
is a complex process where the receptors in the human nose must pick up a scent and also gauge whether it is pleasant or strong by scanning the memory for previous stored memories of scents. Olfactory receptor neurons
leading from the nose to the brain are primarily responsible for this process. Each neuron has the full set of olfactory receptor genes. However, in the process of olfaction; only one of these genes is active in each neuron. Moreover, the genes seem randomly active and vary from neuron to neuron.
New Genome Sequencing Technique
Scientists have long been puzzled by this gene activity wherein each olfactory receptor neuron
only activates a single gene thereby leading to the sensation of smell. The current research study used mouse models to uncover this mysterious olfactory process. Mice have a superior sense of smell as they carry nearly 1000 olfactory receptor genes. These genes are scattered across the genome at 60 different locations on different chromosomes.
Using a new genome sequencing technique called in situ Hi-C
; the researchers were able to 3D map the entire genome inside a living cell. The mapping indicates a cluster of olfactory receptor genes on different chromosomes moving to choose an olfactory receptor gene. Other genetic elements like enhancers are also a part of the process. Enhancers regulate the activities of the genes.
While the research explains the complex process of olfaction, it can also be applied to other biological processes like cancer where genomic translocations (interactions between chromosomes) are known to play a major role. Reference :
- Genes on the Move Help Nose Make Sense of Scents - (https://zuckermaninstitute.columbia.edu/genes-move-help-nose-make-sense-scents)