Fish Scales and Frog Skin For Jaw Bone Repair and Regeneration

Highlights:

At present, lost jaw bone replaced using a patient’s tissues with additional surgery for bone extraction is tiring
Recent research discovered a new alternative biomaterial scaffold using aquaculture waste like fish scales and discarded frog’s skin
This scaffold promotes proper oral tissue regeneration and enhances bone formation with the least inflammatory response

The advent of various biomaterials replacing lost bone makes the bone graft procedure simpler and reduces the need for additional bone harvesting surgery with less time, cost-saving and less pain for patients.

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‘Biomaterial from fish scales and frog skin serves as a new graft substitute material for jaw bone repair and regeneration.’
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What is Bone Grafting Surgery?

Bone grafting procedures are surgical reconstructions carried out using a patient’s tissues to reconstruct a jaw bone defect that doesn’t heal spontaneously or regenerate more than 10% of the lost bone during patients’ lifetime becomes tiring with additional surgery for bone extraction from the patient.

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New Waste-to-resource Bone Graft Substitute

Researchers at Nanyang Technological University (NTU) Singapore develop a new biomaterial using aquaculture KhaiSeng Fish Farm and Jurong Frog Farm, to support Singapore’s circular economy approach towards a zero-waste nation.

The porous biomaterial scaffold is developed combining the hydroxyapatite (HA) from fish scales and Type 1 tropocollagen from frog discarded skin through calcinations process using high heat to remove the organic matter and then air-dried.

When the researchers placed bone-forming cells onto the scaffold, it increased the number of bone cells, indicating that it promotes proper cellular activities and enhances bone formation leading to the formation of new bone tissue.

Using hydroxyapatite (HA), the researchers examining the expression of the gene IL6 in the biomaterial group is negligible, so the risk of triggering an excessive acute inflammatory response is low using this biomaterial.

This research integrates the multiple seafood waste streams into a single high-value product as a sustainable innovation for the aquaculture industry and bringing the waste-to-resource technological pipeline closer to commercialization.

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Postoperative Care Tips for Dental Bone Graft

Applying ice packs to help reduce pain and swelling for the first day or two
Eating soft, bland foods for the first few days
Sleeping with your head slightly elevated to help prevent blood from pooling at the site of the incision.

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Signs of Trouble Post Dental Bone Graft Placement

Pain that persists or worsens several days after the procedure
Redness and increased swelling around the gums
Persistent tingling or numbness
An implant that becomes loose, indicating a previous bone graft has failed.

References:

Fish Scales and Bullfrog Skin Targeted for Oral Tissue Repair - (https://www3.ntu.edu.sg/CorpComms2/Documents/2021/05_May/Dentistry%20Today_210528_bullfrog.pdf)
Ihha induces hybrid cartilage-bone cells during zebrafish jawbone regeneration - (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4920169/)