About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Fecal Microbiota Transplant Helps Treat Cancer Resistant to Immunotherapy
Advertisement

Fecal Microbiota Transplant Helps Treat Cancer Resistant to Immunotherapy

Font : A-A+

Highlights:
  • Fecal microbiota transplant (FMT) is a process of transferring fecal bacteria and microbes from a healthy person into the gastrointestinal tract of the patient
  • It is particularly useful in refractory melanoma patients who have become resistant to anti-PD-1 drugs
  • FMT along with re-induction of anti-PD-1 combination therapy is safe, effective, and feasible

Fecal microbiota transplant promoted the response in immunotherapy refractory melanoma patients, revealed a new study.

Advertisement

Fecal Microbiota Transplant Helps Treat Cancer Resistant to Immunotherapy

Fecal microbiota transplantation(FMT) or stool transplant is the process of transferring fecal bacteria and other microbes from a healthy person into the gastrointestinal tract of the patient. It is effective in the treatment of Clostridium difficile infection and recurrent urinary tract infections (UTIs)

The research conducted at the Ella Lemelbaum Institute for Immuno-Oncology, Sheba Medical Center Israel was published in the journal Science.
Advertisement

Researchers conducted the first in-human studies to analyze whether modifying the gut microbiome by a fecal microbiota transplant can make cancer immunotherapy more effective.

The study which analyzed ten cancer patients with refractory melanoma showed improvement in patient outcomes. Refractory melanoma is a type of melanoma that does not respond to treatment.

According to a Phase 1 clinical trial, a positive response was seen in three out of the ten patients enrolled in the study.

Even though there were some limitations, the authors revealed that the findings support the concept that they can overcome resistance to immunotherapy by modulating the gut microbiota.

Many cancer patients receiving PD-1 inhibitors like atezolizumab, avelumab, and pembrolizumab develop resistance. In normal conditions, PD-1 is expressed on T cells and its binding with a ligand blocks immune activation. Tumor cells also express this PD-1 resulting in the blocking of the immune-mediated killing of tumor cells.

Gut Microbiota Transplant

According to the pre-clinical mouse models and observational studies, one of the most promising methods to overcome resistance to PD-1 inhibitors (anti-PD-1) is by altering the gut microbiome.

No specific class of bacteria has been associated with this response. In pre-clinical models, the transfer of entire gut microbiota from one host to another has shown promising results.

On the basis of this pre-clinical data, Erez N. Baruch and his colleagues designed a Phase 1 clinical trial to evaluate how FMT, which was followed by anti-PD-1 immunotherapy, affected ten patients with metastatic melanoma. These patients have previously become resistant to anti-PD-1 treatment.

The microbiota for transplant was collected from one of two melanoma patients named 'Donor 1' and 'Donor 2' who had previously responded to anti-PD-1 therapy for at least one year. Following transplantation of FMT from Donor 1 or Donor 2, three out of the ten patients responded to anti-PD-1 treatment which was assessed by the decrease in tumor size. The three patients who responded to anti-PD-1 had received FMT from donor 1.

As the study was statically powered to evaluate the safety and not to compare efficiency between donors, the reason for the positive response of transplant from Donor 1 alone is not clear. Baruch and his colleagues have stated that the combination of FMT and re-induction of anti-PD-1 therapy is safe, potentially effective, and feasible.

Reference:
  1. Fecal microbiota transplant promotes response in immunotherapy-refractory melanoma patients: Erez N. Baruch et al: Science Dec(2020).DOI: 10.1126/science.abb5920


Source: Medindia
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Advertisement
News Category
What's New on Medindia
Cervical Cancer Awareness Month 2022
Ultra-Low-Fat Diet
Goji Berries May Protect Against Age-Related Vision Loss
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Cancer and Homeopathy Immunisation Cancer Facts Cancer Tattoos A Body Art Dealing with Pollen Allergy Stool Test Common Lifestyle Habits that Cause Diseases Health Benefits of Dandelion Plant Neck Cracking 

Recommended Reading
New Immunotherapy Treatment for Genitourinary Cancer
New immunotherapy medications used for the treatment of kidney, bladder and prostate cancer include ...
New Era in Cancer Treatment Arising With the Use of Nanobiologic Immunotherapy
Immunotherapy can train the immune system to fight the cancer cells....
Age-dependent Cancer Therapy: A Key Element in Treatment-resistant Melanoma
Age is a key factor in determining the efficiency of targeted therapy for Melanoma. Inhibition of .....
Home Remedies for Urinary Tract Infection
Are you suffering from urinary tract infection (UTI)? Read on to know how simple home remedies can ....
Common Lifestyle Habits that Cause Diseases
Cigarette smoking, unhealthy diets, overuse of alcohol, and physical inactivity are some of the most...
Dealing with Pollen Allergy
The plants around you that give you sniffles in your nose at specific time of the year are the sourc...
Health Benefits of Dandelion Plant
What is dandelion? Dandelion greens are nutrition powerhouses with a wide range of health benefits. ...
Neck Cracking
Neck cracking or neck popping is caused by quick movements to loosen the ligaments and joints of the...
Stool Test
Faecal matter may be subjected to occult blood tests, microbiology tests, and chemical tests and c...
Tattoos A Body Art
Tattoos are a rage among college students who sport it for the ‘cool dude’ or ‘cool babe’ look...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2022

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use
open close
ASK A DOCTOR ONLINE
I have read and I do accept terms of use - Telemedicine

Advantage Medindia: FREE subscription for 'Personalised Health & Wellness website with consultation' (Value Rs.300/-)