uncover a critical step in the molecular process of aging to repair the
- New revolutionary
drug is capable of allowing the cells to improve DNA repair and reverse
- The drug is found
to benefit survivors of childhood cancers and also help NASA astronauts
from cosmic radiation.
The discovery of a
novel, revolutionary drug from the University of New South Wales, reverses
aging, improves DNA repair
even help NASA astronauts to travel Mars.
The research team
uncovers a critical step in the molecular process which is capable of allowing
the cells to repair the damaged DNA. The research study was published in the
‘Revolutionary drug found to reverse aging and improve DNA repair. The drug may benefit NASA astronauts from cosmic radiation.’
The experiments that
were carried out in mice suggested, a possible treatment for DNA damage that occurs
due to aging and radiation. The results of the experiment were promising and
had attracted the NASA astronauts. They even believe that the new treatment can
help in its Mars mission.
The cells in our body
have an innate capability to repair the DNA damage. However, the ability to
repair may decline as we age.
By treating the mice
with the NAD+ precursor, or ' booster;' called NMN (Nicotinamide
mononucleotide), the ability of the cells, to repair the DNA damage caused by
radiation exposure or old age, improved.
Sinclair, UNSW School of Medical Sciences and Harvard Medical School Boston,
said, "The cells of the old mice were indistinguishable from the young
mice, after just one week of treatment."
The clinical trials of
NMN Therapy will begin within six months.
"This is the closest we are to a safe and effective anti-aging drug that's
perhaps only three to five years away from being on the market if the trials go
On the Verge of Discovering an Anti-aging Pill: NMN Therapy
Professor Sinclair and
Dr. Wu have been working for the past four years, to make the NMN therapy into
a drug substance or a pill for anti-aging.
The clinical trials for
the drug will begin at the Brigham and Women's Hospital, in Boston.
The study findings on
NAD+ and NMN were found to add value to the aging research. The research team looked
at the interplay of the number of proteins and molecules involved in the aging
They also established
the role of NAD+ in treating various diseases of aging, female infertility and
side effects of chemotherapy.
found a link between the anti-aging enzyme SIRT1 and resveratrol which is a
naturally occurring molecule present in red wine, in 2003.
He added, "While
resveratrol activates SIRT1 alone, NAD+ boosters activate all seven sirtuins,
SIRT1-7, and should have an even greater impact on health and longevity."
Benefits of NMN Therapy
The theory may alleviate
the damage caused by the DNA in frequent flyers and may also benefit survivors
of childhood cancer.
Around 96% of childhood
cancer survivors would suffer from chronic illness by age 45, this may type 2
, Alzheimer's disease
,other types of cancer and
Dr.Wu said, "All of
this adds up to the fact they have accelerated aging, which is
"It would be great
to do something about that, and we believe we can with this molecule."
Why is NASA Excited?
The National Aeronautics
and Space Administration (NASA) is an independent agency of the United States
of America and is well known for its aerospace research.
The research work on NMN
therapy has excited NASA because of the challenge it faces to keep astronauts
safe and healthy during a four-year mission to Mars.
NASA astronauts, even on
a short mission, may experience an accelerated aging from cosmic radiation.
They may suffer from
- Muscle weakness
- Memory loss when
they return from space
Moreover, a trip to Mars
would make the condition even worse resulting in a
- 5% cell death
- 100% chance for
Professor Sinclair and
his colleague Dr. Lindsay Wu, came up with a solution for the problem and even
won the NASA iTech competition last year.
Cosmic rays are
subatomic particles that arrive with a variety of energies from outside the
Earth's atmosphere. The radiation emitted is not only an issue for astronauts,
but also for people during air travel. It is roughly estimated that the
London-Singapore-Melbourne flight may emit cosmic rays equivalent to a
radiation of a chest X-ray.
- Jun Li, Michael S. Bonkowski, Sébastien Moniot,
Dapeng Zhang, Basil P. Hubbard, Alvin J. Y. Ling, Luis
A. Rajman, Bo Qin, Zhenkun Lou, Vera Gorbunova, L. Aravind, Clemens Steegborn,
David A. Sinclair. A conserved
NAD binding pocket that regulates protein-protein interactions during aging.
Science, 24 Mar (2017): Vol. 355, Issue
6331, pp. 1312-1317 DOI:
- What are Cosmic Rays? - (http://www.telescopearray.org/index.php/about/what-are-cosmic-rays)