About Careers Internship MedBlogs Contact us
Excess Folate Intake Associated With Peripheral Neuropathy In Older Adults

Excess Folate Intake Associated With Peripheral Neuropathy In Older Adults

Font : A-A+

  • Excessive consumption of folate can increase the risk of nerve damage disorder in older adults with a genetic variation.
  • People who carry two copies of a genetic variation in TCN2 are likely to have vitamin B12 deficiency.
  • Individuals with the TCN2 variation, who consumed more folate a day had seven-fold higher odds for peripheral neuropathy.
  • Older adults should try to get folate from a balanced diet rather than depending on supplements or fortified food.

Folate Vitamin B9 is an essential nutrient that plays a vital role in many bodily functions such as DNA synthesis and repair, cell and tissue growth, and supports reproductive health, cardiovascular and neural health.

It is important to consume the daily recommended level of vitamins and minerals for the proper functioning of the body. But consumption of nutrients more than the recommended levels may be harmful.


Excessive intake of folate is linked to nerve damage risk in older adults with a common genetic variant, according to a new study.

Genetic Variation in TCN2

People who carry a genetic variation in TCN2 are more likely to suffer from nerve damage. The gene TCN2 codes for a vitamin B12 transport protein. People with TCN2 variation also referred as GG can cause vitamin B12 deficiency, even if they consume recommended levels of vitamin B12.

In the United States, one in six people carry two copies of genetic variation in TCN2.

High Folate Intake Associated with Increased Risk of Peripheral Neuropathy

A team of scientists from the Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts (USDA HNRCA) conducted an epidemiological study among older adults. The study involved 171 adults aged 60 and older.

The researchers focused on participants who consumed more than twice the Recommended Dietary Allowance (RDA) of 800 micrograms of folate a day. Out of 171 individuals in the study population, 31 had GG variant.

The risk of peripheral neuropathy was seven-fold higher for individuals with the GG variant. The researchers found no significant difference in odds among participants who consumed less than 800 micrograms of folate a day.

Ligi Paul, Ph.D., scientist in the Vitamin Metabolism Laboratory at the USDA HNRCA, and senior author of the study, said, "Due to the prevalence of the TCN2 variant, and because the average daily folate intake for US adults over 50 is already more than twice the RDA, we believe that our findings highlight a potential concern for a large proportion of older Americans."

"Our data suggest that older adults should keep folate intake close to the recommended amounts, and try to get nutrients from a balanced diet rather than depending on supplements," said Paul.

Vitamin B12 Deficiency in Older Adults

Vitamin B12 deficiency is more common among older adults due to decreased stomach acid production and some medications that interfere with the absorption of the vitamin from food.

Vitamin B12 is known to cause anemia and peripheral neuropathy. Consumption of folate can alleviate anemia caused by vitamin B12 deficiency. But studies conducted earlier have shown that high folate consumption could worsen neurological deficits, including peripheral neuropathy in older adults.

The new findings add evidence to the previous studies. The researchers suggest that older adults should be careful about their folate intake.

Hathairat Sawaengsri, Ph.D., of USDA HNRCA and lead author of the study, said, "Folate is a necessary vitamin and no one should think that it needs to be avoided. But in certain situations, very high intake of folate may be harmful. Vitamins and minerals should be consumed at an optimal level--not too high and not too low."

The findings of the study add to the growing evidence that high and low intake of folate can cause negative health outcomes. In the previous study conducted in mice, the researchers found that excess folic acid consumption was associated with shortening of protective structures (telomeres) on human chromosomes and can reduce the ability of the immune system to destroy cells infected by viruses.

The study is published in the American Journal of Clinical Nutrition.

Peripheral Neuropathy

Peripheral neuropathy is a nerve damage associated with vitamin B12 deficiency. Peripheral neuropathy is characterized by weakness, numbness, and pain in the hands and feet. Some of the other causes of peripheral neuropathy include infections, diabetes, traumatic exposure, inherited causes and exposure to toxins.

Food Sources of Folate

Folate is a water-soluble B vitamin that is naturally found in foods. It is an essential nutrient especially for infants, children and pregnant women (to prevent birth defects). Folate is the term for both naturally occurring in food and the synthetic form called as folic acid, which is found in fortified foods and supplements.

Approximately 35 percent of the adults in the US consume folic acid in dietary supplements, according to the National Institute of Health's Office of Dietary Supplements. Adults over the age of 50 years are at risk of consuming excess folate. The Dietary Guidelines for Americans advises that nutrients are best obtained from natural food sources. Some of the food sources of folate include,
  • Liver, poultry, and pork
  • Spinach, kale, cabbage, broccoli, asparagus, okra
  • Beans and legumes
  • Whole grain foods
  • Orange and orange juice, strawberries
Source: Medindia

Citations   close

Please use one of the following formats to cite this article in your essay, paper or report:

  • APA

    Shirley Johanna. (2016, October 12). Excess Folate Intake Associated With Peripheral Neuropathy In Older Adults. Medindia. Retrieved on May 24, 2022 from https://www.medindia.net/news/healthinfocus/excess-folate-intake-associated-with-peripheral-neuropathy-in-older-adults-164233-1.htm.

  • MLA

    Shirley Johanna. "Excess Folate Intake Associated With Peripheral Neuropathy In Older Adults". Medindia. May 24, 2022. <https://www.medindia.net/news/healthinfocus/excess-folate-intake-associated-with-peripheral-neuropathy-in-older-adults-164233-1.htm>.

  • Chicago

    Shirley Johanna. "Excess Folate Intake Associated With Peripheral Neuropathy In Older Adults". Medindia. https://www.medindia.net/news/healthinfocus/excess-folate-intake-associated-with-peripheral-neuropathy-in-older-adults-164233-1.htm. (accessed May 24, 2022).

  • Harvard

    Shirley Johanna. 2021. Excess Folate Intake Associated With Peripheral Neuropathy In Older Adults. Medindia, viewed May 24, 2022, https://www.medindia.net/news/healthinfocus/excess-folate-intake-associated-with-peripheral-neuropathy-in-older-adults-164233-1.htm.


News A-Z
What's New on Medindia
Can Weight Loss be Achieved by Drinking Water?
Can Exercise Counts Boost Your Life Counts? 
Prevent Hacking of Medical Devices: FDA Sounds Alarm
View all
Recommended Reading
News Archive
News Category

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Iron & Folate Deficiency Anemia In Pregnancy Diet for Anemia in Pregnancy Diamond Blackfan Anemia Peripheral Neuropathy 11 Alarming Symptoms & Signs You Should Look Out For Nerve Damage Drug-Induced Neuropathy Allodynia 

Most Popular on Medindia

Selfie Addiction Calculator Noscaphene (Noscapine) How to Reduce School Bag Weight - Simple Tips Turmeric Powder - Health Benefits, Uses & Side Effects Diaphragmatic Hernia Drug Side Effects Calculator Loram (2 mg) (Lorazepam) The Essence of Yoga Hearing Loss Calculator Blood Pressure Calculator

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2022

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use
open close