- Dehydration due to diarrhea is one of the leading cause for infant and child mortality in developing countries.
- Newly developed DHAKA score to assess dehydration in children has shown very good accuracy, sensitivity and specificity.
- DHAKA score helps pick out cases of severe dehydration in whom the limited resources can be used.
- Mild to moderate dehydration can be treated with oral rehydration therapy (ORT) at home.
Why Is It Important to Diagnose DehydrationDehydration occurring due to diarrhea is one of the leading causes of infant mortality in the developing countries. It is important to recognize a severely dehydrated child in the midst of seeing several cases on a busy day, and institute prompt treatment. It may help save many precious young lives.
The Dhaka 2014 Study in BriefThis study was conducted by Dr. Adam Levine, associate professor of emergency medicine in the Warren Alpert Medical School of Brown University. He was assisted by a team at the International Centre for Diarrhoeal Disease Research in Dhaka, Bangladesh.
The study analyzed 771 children with diarrhea due to various causes including cholera and severe intestinal infections.
They zeroed in on four such symptoms that a nurse or doctor could observe in less than two minutes to make an accurate diagnosis. These included -
- General appearance: Is the child restless or irritable, or lethargic or unconscious?
- Breathing: Is it normal or deep?
Skin pinch: After a pinch, does skin -
- snap right back
- or respond slowly,
- or very slowly?
- Tears: Does the child produce a normal volume, less than normal or none at all
Signs and Symptoms of Severe Dehydration in Children
The usual described symptoms of severe dehydration include -
Some of these can be fatal -
Results of the Dhaka 2014 StudyWhen analyzed to see how predictive they were of dehydration severity, the tool scored well. On an overall measure of accuracy called AUC, which ranges from 0 to 1, the DHAKA score rated a 0.8 for severe dehydration. The score's sensitivity, on a percentage scale, was 83 percent for severe dehydration.
This study also retrospectively compared the admission weight and the post-rehydration weight and calculated the percent weight gain and found that the results correlated perfectly with percent volume loss.
It is now the most tested method and scores over the current standard, the World Health Organization's Integrated Management of Childhood Illness (IMCI) guidelines.
Results of Validation Studies Conducted in 2015
Dr Levine returned to Dhaka in 2015 to validate the DHAKA score by testing its predictive value with an entirely new population of 496 patients.
This study was carried out to determine whether the scoring method would work for any group of patients, not just the ones from whom it was derived in the 2014 study.
Nurses employed both the DHAKA score and IMCI algorithm when new patients arrived.
On a statistical scale of accuracy, where 0.5 is no better than chance and 1 is perfect, DHAKA rated 0.82 while IMCI rated 0.76.
Why the Dhaka Study and DHAKA Score are Significant
This is the first score to be derived and validated in a low-income country setting where most diarrheal epidemics occur.
Also, the DHAKA study is the largest study ever of dehydration assessment of kids anywhere, with over 1200 children studied including both the derivation and validation studies.
Final Study Planned in 2016
Dr Levine plans to return again to Dhaka in the spring of 2016. That is the time of the year when the scourge of cholera attacks Bangladesh every year.
This time, he plans to test it in rural clinics of Bangladesh. He plans to determine if the DHAKA scoring is simple enough to use in the rural clinics where there isn't the same degree of training and experience as at the center in Dhaka.
If the study proves successful, Dr Levine hopes to earn the WHO's endorsement to use DHAKA as the new diagnostic standard in clinics low on resources and high on caseloads.