Mental health is
a serious health condition that affects a considerable number of people
worldwide. This condition affects the way the individual behaves, thinks and
speaks and affects the ability to carry out a task.
- Mental health affects people as
early as 15 years of age with one in every 5 individual affected.
in 20 people may be affected with a serious mental illness like schizophrenia.
growth and behavior characteristics of teenagers sometime hide issues
associated with mental illness.
- According to WHO
statistics for 2008, neuropsychiatric diseases contributed 11.8% to the global
burden of disease.
- As age advances, there is an increased
risk for mental illness characterized by dementia and memory loss.
is important to the well being of an individual as it helps
them function well. Most of the time, the symptoms associated with mental
health illness are masked by other factors or associated conditions which lead
to increase in severity of the condition.
‘A diagnostic blood test has been designed to identify patients with severe mental illness.’
Moreover, doctors prescribe anti-depressants
based on certain signs and symptoms which
are relatively ambiguous, leading to a trial and error method of drug
prescription. A new study conducted by researchers Maffioletti E and colleagues
from the Institute of Psychiatry at the King's College London has identified a
simple blood test that could determine if an individual requires
illnesses like severe mental disorder (MD) and bipolar
(BD) are illnesses that
require anti-depressants. MicroRNAs or miRNAs are small non-coding RNAs that
post transcriptionally regulate the synthesis of protein by binding with target
studied the presence of these miRNAs in the blood of individuals with severe
mental disorder and bipolar disorder. For the study, 20 individuals with MD, 20
individuals with BD and 20 healthy controls were recruited.
The study found
that among MD patients the following 5 miRNAs were altered,
The following 5
miRNAs were altered among patients with BD,
2 miRNAs were
altered for both MD and BD patients,
prediction analysis was performed by the researchers to find the genes
associated with the miRNAs. The genes were found to influence neuropsychiatric
pathways which are affected by severe mental disorder and bipolar disorder.
Of The Study
- The miRNAs were dysregulated in
mood disorders, opening the doorway to a better understanding of such
- The development of a blood test
to detect severe mental disorder will remove ambiguity in care provided.
mental illness will become easier
- The study shows that
mental health illness is not only psychiatric but the effects include changes
to the whole body.
test will provide conclusive evidence for specialized medical care which could
avert progression of the condition. After all, good mental health will aid the
individual in leading a better quality of life
- Peripheral whole blood
microRNA alterations in major depression and bipolar